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Cover Figure

ONLINE COVER This week, Science Signaling publishes a Focus Issue on the various signaling pathways that enable cells to sense environmental cues and direct their migration accordingly. Highlights include a Research Article by Morinaka et al. that uncovers the requirement for redox signaling in axonal growth cone collapse, a Perspective by Afonso and Parent that proposes a context-dependent role for phosphatidylinositol 3-kinase in migration and chemotaxis, a Perspective by Muller that discusses the complicated array of signals that guide neutrophils to injured tissue, and a Journal Club article by Byron that describes the architecture of adhesion complexes. The image shows a dorsal root ganglion neuron stained for thioredoxin (green) and F-actin (red). [Image: Akifumi Morinaka and Hiroaki Miki, Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882