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Editors' Choice

Nancy R. Gough
3 May 2011: ec122.
Transactivation of receptor tyrosine kinases by G protein–coupled receptors does not always result in internalization. Abstract »  
Annalisa M. VanHook
3 May 2011: ec123.
Mathematical modeling identifies a robust mechanism for coordinating regeneration across a large tissue. Abstract »  
Wei Wong
3 May 2011: ec124.
Dectin-1 initiates antifungal responses only when bound to the particulate form of its ligand. Abstract »  
Kristen L. Mueller
3 May 2011: ec125.
An inhibitory T cell receptor acts by stripping activating ligands off dendritic cells. Abstract »  
Valda Vinson
3 May 2011: ec126.
The topology of this molecular interface provides a foundation for the design of therapeutics against autoreactive B cells. Abstract »  
Annalisa M. VanHook
3 May 2011: ec127.
O-glucosylation modulates the activity of mammalian Notch. Abstract »  

 

Podcasts

Thomas C. Mitchell and Annalisa M. VanHook
3 May 2011: pc9.
Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. Abstract »   Full Text »   Podcast »  

 

Research Articles

Petra Weissgerber, Ulrich Kriebs, Volodymyr Tsvilovskyy, Jenny Olausson, Oliver Kretz, Christof Stoerger, Rudi Vennekens, Ulrich Wissenbach, Ralf Middendorff, Veit Flockerzi, and Marc Freichel
3 May 2011: ra27.
Production of functional spermatozoa requires regulation of the Ca2+ concentration in epididymal fluid by TRPV6. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Chelsea A. Embry, Luigi Franchi, Gabriel Nuñez, and Thomas C. Mitchell
3 May 2011: ra28.
Biased signaling by an immune receptor ligand underlies its inability to induce inflammatory responses. Editor's Summary »   Abstract »   Full Text »   PDF »  

 

Perspectives

Elena Rainero and Jim C. Norman
3 May 2011: pe24.
The rate at which morphogen receptors move into lysosomes dictates the extent of downstream signaling during differentiation. Abstract »   Full Text »   PDF »  
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