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Editors' Choice

John F. Foley
24 May 2011: ec145.
Stress induces the proteolysis of the receptor tyrosine kinase EphB2 in the amygdala to promote anxiety. Abstract »  
Stella M. Hurtley
24 May 2011: ec146.
A cellular compartment allows simultaneous protein synthesis and degradation. Abstract »  
Kristen L. Mueller
24 May 2011: ec147.
Signaling through innate immune receptors promotes commensal bacteria colonization of the gut. Abstract »  
Wei Wong
24 May 2011: ec148.
CLAVATA3 peptide acts as a "vaccination" to activate pathogen defense pathways in plant shoot apical meristems. Abstract »  
Elizabeth M. Adler
24 May 2011: ec149.
Different DNA-damaging stimuli can lead to different p53 dynamics that can be explained by features of the underlying networks. Abstract »  
Annalisa M. VanHook
24 May 2011: ec150.
Distinct histone modifications influence the liver-versus-pancreas fate choice of endodermal cells. Abstract »  



James F. Martin, Valeri Vasioukhin, Mark R. Silvis, and Annalisa M. VanHook
24 May 2011: pc10.
Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. Abstract »   Full Text »   Podcast »  


Research Articles

Mark R. Silvis, Bridget T. Kreger, Wen-Hui Lien, Olga Klezovitch, G. Marianna Rudakova, Fernando D. Camargo, Dan M. Lantz, John T. Seykora, and Valeri Vasioukhin
24 May 2011: ra33.
A cell-cell adhesion protein suppresses skin carcinoma development by attenuating the signaling of a transcriptional coactivator in the Hippo pathway. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Huei-Chi Wen, Alvaro Avivar-Valderas, Maria Soledad Sosa, Nomeda Girnius, Eduardo F. Farias, Roger J. Davis, and Julio A. Aguirre-Ghiso
24 May 2011: ra34.
The kinase p38α may suppress breast cancer by promoting formation of the proper architecture of mammary glands. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Michael O. Hottiger, Mark Boothby, Friedrich Koch-Nolte, Bernhard Lüscher, Niall M. B. Martin, Ruth Plummer, Zhao-Qi Wang, and Mathias Ziegler
24 May 2011: mr5.
Scientists gathered in Zurich, Switzerland, to discuss new insights into cell, structural, and developmental biology of ADP-ribosylation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882