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Editors' Choice

Elizabeth M. Adler
7 June 2011: ec157.
Pyruvate kinase M2 interacts directly with hypoxia-inducible factor 1 to promote glycolytic metabolism. Abstract »  
Annalisa M. VanHook
7 June 2011: ec158.
HIF-α interacts with Notch to specify the fate of blood cells in the fly. Abstract »  
John F. Foley
7 June 2011: ec159.
The proapoptotic protein Bid promotes innate immune responses in the intestine independently of its role in apoptosis. Abstract »  
Annalisa M. VanHook
7 June 2011: ec160.
mTOR phosphorylates an RNA binding protein in a raptor-independent manner to stimulate translation of an insulin-like growth factor. Abstract »  
Jake Yeston
7 June 2011: ec161.
Vibrational spectroscopy coupled with isotopic substitution can probe protein structure. Abstract »  

 

Research Articles

Liqun Ma, Xuexin Zhang, and Haijun Chen
7 June 2011: ra37.
Very low extracellular K+ concentrations, which can trigger cardiac arrhythmias, cause TWIK-1 potassium channels to become permeable to Na+. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
David S. Parker, Michael A. White, Andrea I. Ramos, Barak A. Cohen, and Scott Barolo
7 June 2011: ra38.
Reporter gene assays in Drosophila and modeling reveal mechanisms that control transcriptional responses to gradients of Hedgehog ligands. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Omer Dushek, Milos Aleksic, Richard J. Wheeler, Hao Zhang, Shaun-Paul Cordoba, Yan-Chun Peng, Ji-Li Chen, Vincenzo Cerundolo, Tao Dong, Daniel Coombs, and Philip Anton van der Merwe
7 June 2011: ra39.
Efficient T cell activation depends on the rate with which T cell receptors and antigens bind and unbind, rather than simply their equilibrium affinity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Thomas Whitington, Arttu Jolma, and Jussi Taipale
7 June 2011: pe29.
Transcription factor binding site affinity has a counterintuitive effect on the regulation of gene expression in response to Hedgehog. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882