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Editors' Choice

John F. Foley
14 June 2011: ec162.
The transcriptional regulators YAP and TAZ relay mechanical cues from the environment to the nucleus. Abstract »  
Elizabeth M. Adler
14 June 2011: ec163.
The sudden loss of mechanical force in severed tendons leads to release of TGF-β and massive tenocyte death. Abstract »  
Nancy R. Gough
14 June 2011: ec164.
The bactericidal activity of mammalian peptidoglycan recognition proteins involves activation of a bacterial two-component stress defense pathway. Abstract »  
L. Bryan Ray
14 June 2011: ec165.
A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression. Abstract »  
Peter R. Stern
14 June 2011: ec166.
Nicotine decreases weight gain by targeting a brain pathway involved in the regulation of energy balance and food intake. Abstract »  
Valda K. Vinson
14 June 2011: ec167.
Thermal activation of visual pigments involves the same chromophore-isomerization reaction as does light activation. Abstract »  
L. Bryan Ray
14 June 2011: ec168.
A screen identifies proteins not previously known to function in protecting cells from DNA damage. Abstract »  

 

Podcasts

Richard Treisman, Neil Q. McDonald, Stéphane Mouilleron, and Annalisa M. VanHook
14 June 2011: pc11.
Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. Abstract »   Full Text »   Podcast »  

 

Research Articles

Stéphane Mouilleron, Carola A. Langer, Sebastian Guettler, Neil Q. McDonald, and Richard Treisman
14 June 2011: ra40.
Binding of multimeric actin inhibits a transcriptional coactivator by promoting nuclear export and blocking nuclear import. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Susanna Stinson, Mark R. Lackner, Alex T. Adai, Nancy Yu, Hyo-Jin Kim, Carol O’Brien, Jill Spoerke, Suchit Jhunjhunwala, Zachary Boyd, Thomas Januario, Robert J. Newman, Peng Yue, Richard Bourgon, Zora Modrusan, Howard M. Stern, Søren Warming, Frederic J. de Sauvage, Lukas Amler, Ru-Fang Yeh, and David Dornan
14 June 2011: ra41.
The microRNAs miR-221 and miR-222 promote a phenotype associated with metastasis and are found in a clinically aggressive form of breast cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Gwyn W. Gould
14 June 2011: pe30.
IKK{varepsilon}-mediated phosphorylation events may redirect endosomal traffic by switching the motor proteins associated with vesicles. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882