14 June 2011
Vol 4, Issue 177

About The Cover

Cover image expansion

Online Cover This week features a Research Article describing how the binding of multimeric actin inhibits the transcriptional coactivator MRTF-A by promoting nuclear export and blocking nuclear import. The image shows the structure of the actin-binding domain of MRTF-A bound to five actin monomers (PDB code 2YJF). [Image: Stéphane Mouilleron, Structural Biology Group, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, UK]