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Cover Figure

ONLINE COVER This week features a Research Article describing how the binding of multimeric actin inhibits the transcriptional coactivator MRTF-A by promoting nuclear export and blocking nuclear import. The image shows the structure of the actin-binding domain of MRTF-A bound to five actin monomers (PDB code 2YJF). [Image: Stéphane Mouilleron, Structural Biology Group, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London, UK]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882