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Editors' Choice

Elizabeth M. Adler
21 June 2011: ec169.
PTEN regulates DNA damage–induced cell size arrest through a mechanism independent of its ability to decrease Akt phosphorylation. Abstract »  
Nancy R. Gough
21 June 2011: ec170.
N-terminal palmitoylation appears to position multimeric complexes of Sonic hedgehog such that protease cleavage alleviates an autoinhibitory interaction. Abstract »  
John F. Foley
21 June 2011: ec171.
Detection of prokaryotic mRNA by the host distinguishes between live and dead microorganisms and enhances the immune response. Abstract »  
Pamela J. Hines
21 June 2011: ec172.
Targeted degradation of bacterial sensing proteins keeps plant defenses from running amok. Abstract »  
Wei Wong
21 June 2011: ec173.
A nuclear pore component maintains an inactive pool of the cAMP effector Epac1 at the nuclear envelope. Abstract »  
L. Bryan Ray
21 June 2011: ec174.
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate. Abstract »  
Stella M. Hurtley
21 June 2011: ec175.
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation. Abstract »  
L. Bryan Ray
21 June 2011: ec176.
New cogs in the mammalian circadian clock are identified. Abstract »  
Guy Riddihough
21 June 2011: ec177.
A genome stability regulator integrates DNA repair and stress signaling pathways. Abstract »  


Journal Club

Shashikanth M. Sriram, Dong Hoon Han, and Sung Tae Kim
21 June 2011: jc4.
Toll-like receptor 4 signaling provides insights into the molecular mechanism of ubiquitin-dependent selective autophagy. Abstract »   Full Text »   PDF »  



Young-Gun Yoo, Jared Christensen, Jie Gu, and L. Eric Huang
21 June 2011: pt4.
Hypoxia-induced genetic alterations induce epithelial-mesenchymal transition and tumor progression. Abstract »   Full Text »   PDF »   Slideshow »  


Research Resources

Michael H. Tatham, Ivan Matic, Matthias Mann, and Ronald T. Hay
21 June 2011: rs4.
Changes in cellular SUMOylation occur in response to the accumulation of misfolded proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882