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Cover Figure

ONLINE COVER This week features a Research Resource reporting a proteomic analysis of SUMOylation in response to inhibition of the proteasome that suggested that the ubiquitin-like protein SUMO participates in the cellular response to stresses that promote accumulation of misfolded proteins. The image shows the structure of human SUMO-1 based on Protein Data Bank ID 1Y8R. [Image: Chris Bickel, AAAS].

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882