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Editors' Choice

Elizabeth M. Adler
28 June 2011: ec178.
The Pom1 cortical concentration gradient depends on its autophosphorylation and its dephosphorylation by Dis2. Abstract »  
L. Bryan Ray
28 June 2011: ec179.
Phosphorylation of the yeast centrosome reveals sites of regulation and predicts complex regulation of mammalian centrosomes. Abstract »  
Nancy R. Gough
28 June 2011: ec180.
NLRX1 attenuates inflammatory signaling in response to infection by dampening signals from both TLR4 and RIG-1 receptors for pathogen-associated molecules. Abstract »  
Nancy R. Gough
28 June 2011: ec181.
The yolk protein phosvitin acts as a pattern recognition receptor to help developing fish fend off bacterial infection. Abstract »  
Wei Wong
28 June 2011: ec182.
Acetylation of pyruvate kinase M2 inhibits its activity and triggers its autophagic degradation, leading to increased tumor cell proliferation. Abstract »  
Valda Vinson
28 June 2011: ec183.
An implanted device using blue-light–triggered expression of the glucagon-like peptide 1 attenuates diabetes in mice. Abstract »  


Editorial Guides

Nancy R. Gough
28 June 2011: eg5.
Research into the phosphoproteome targeted by mitotic kinases reveals insight into the coordination of the activity of these kinases during cell division. Abstract »   Full Text »   PDF »  



Silke Hauf, Mark Winey, Michele H. Jones, Jamie M. Keck, and Annalisa M. VanHook
28 June 2011: pc12.
Two studies shed light on cell cycle–dependent protein phosphorylation during mitosis in yeast. Abstract »   Full Text »   Podcast »  


Research Articles

Jes Alexander, Daniel Lim, Brian A. Joughin, Björn Hegemann, James R. A. Hutchins, Tobias Ehrenberger, Frank Ivins, Fabio Sessa, Otto Hudecz, Erich A. Nigg, Andrew M. Fry, Andrea Musacchio, P. Todd Stukenberg, Karl Mechtler, Jan-Michael Peters, Stephen J. Smerdon, and Michael B. Yaffe
28 June 2011: ra42.
Mitotic kinases that localize to the same compartment show negative selectivity for residues in each other’s recognition motifs. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Louise N. Johnson
28 June 2011: pe31.
Research provides insight into how substrate selectivity of the multiple kinases that control mitosis is achieved. Abstract »   Full Text »   PDF »  


Research Resources

Arminja N. Kettenbach, Devin K. Schweppe, Brendan K. Faherty, Dov Pechenick, Alexandre A. Pletnev, and Scott A. Gerber
28 June 2011: rs5.
Combining quantitative phosphoproteomics and selective kinase inhibition yields previously unknown substrates and functions of two families of mitotic kinases and refinement of their recognition motifs. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
André Koch, Karsten Krug, Stuart Pengelley, Boris Macek, and Silke Hauf
28 June 2011: rs6.
System-wide analysis of proteins phosphorylated by the mitotic kinase Aurora in fission yeast suggests widespread functions for this kinase in regulating chromatin dynamics. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882