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Editors' Choice

Wei Wong
5 July 2011: ec184.
Sialylation of Fas may enable colon carcinoma cells to evade apoptosis. Abstract »  
Nancy R. Gough
5 July 2011: ec185.
Insulin-responsive neurons in the ventromedial hypothalamus contribute to obesity induced by a high-fat diet. Abstract »  
John F. Foley
5 July 2011: ec186.
Targeting of caveolin-1 by microRNAs destabilizes the insulin receptor, which leads to decreased insulin sensitivity. Abstract »  
Guy Riddihough
5 July 2011: ec187.
An in vitro system reveals the steps involved in repairing covalent links between DNA strands of the double helix. Abstract »  
Peter R. Stern
5 July 2011: ec188.
Specific neuronal populations in the amygdala control different behavioral and physiological components of the fear response. Abstract »  

 

Podcasts

Yuanzheng He and Annalisa M. VanHook
5 July 2011: pc13.
The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. Abstract »   Full Text »   Podcast »  

 

Research Articles

Ying Su, Jason K. Ospina, Junzheng Zhang, Andrew P. Michelson, Adam M. Schoen, and Alan Jian Zhu
5 July 2011: ra43.
It takes two kinases and two phosphatases acting on a single membrane protein Smoothened to interpret the Hedgehog morphogen gradient. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yuanzheng He, Yong Xu, Chenghai Zhang, Xiang Gao, Karl J. Dykema, Katie R. Martin, Jiyuan Ke, Eric A. Hudson, Sok Kean Khoo, James H. Resau, Arthur S. Alberts, Jeffrey P. MacKeigan, Kyle A. Furge, and H. Eric Xu
5 July 2011: ra44.
Inhibition of lysosome function promotes the anti-inflammatory effects of glucocorticoid signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Cammie F. Lesser and John M. Leong
5 July 2011: pe32.
Bacterial effector proteins can act as novel scaffolds for signaling proteins in infected mammalian cells. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882