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ONLINE COVER This week features a Research Article that describes a mechanism by which lysosomes influence glucocorticoid signaling, which explains why the lysosomal inhibitor chloroquine is an effective anti-inflammatory agent. The image shows the lysosomes (green) and the glucocorticoid receptor (red). [Image: Eric Hudson, Laboratory of Analytical, Cellular, and Molecular Microscopy, Van Andel Research Institute]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882