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Editors' Choice

John F. Foley
12 July 2011: ec189.
NF-{kappa}B signaling in distinct neurons in the hypothalamus forms the link between obesity and hypertension. Abstract »  
Heather M. Thompson
12 July 2011: ec190.
Activation of receptor tyrosine kinases may not be enough for oncogenesis; excess signaling from endosomes may also be required. Abstract »  
Nancy R. Gough
12 July 2011: ec191.
Nitric oxide synthase-2 is a proliferation-promoting marker of glioma stem cells. Abstract »  
Elizabeth M. Adler
12 July 2011: ec192.
Oncogenes can activate a reactive oxygen species-detoxification program to promote tumorigenesis. Abstract »  
Wei Wong
12 July 2011: ec193.
The lipid phosphatase-dependent and independent functions of PTEN are activated and inhibited, respectively, by the adaptor protein β-arrestin. Abstract »  
Stella M. Hurtley
12 July 2011: ec194.
Phosphorylation of an autophagy receptor restricts pathogenic cytosolic bacterial growth. Abstract »  


Research Articles

Qin Liu, Hao-Jui Weng, Kush N. Patel, Zongxiang Tang, Haihua Bai, Martin Steinhoff, and Xinzhong Dong
12 July 2011: ra45.
Sensory neurons perceive itch and heat-induced pain through two different receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Eric A. Johnson
12 July 2011: pe33.
The interaction of the transcription factor HIF-α with the Notch receptor promotes cell fate specification and maintenance. Abstract »   Full Text »   PDF »  


Research Resources

Ma. Xenia G. Ilagan, Sora Lim, Mary Fulbright, David Piwnica-Worms, and Raphael Kopan
12 July 2011: rs7.
Luciferase complementation imaging enables quantitative analyses of Notch pathway dynamics in real time in living cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882