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Editors' Choice

Elizabeth M. Adler
19 July 2011: ec195.
The exact timing of a modulatory cholinergic signal is crucial to its effects on synaptic plasticity. Abstract »  
Wei Wong
19 July 2011: ec196.
Suppression of TGF-β signaling causes white adipose tissue to adopt properties characteristic of brown adipose tissue. Abstract »  
Annalisa M. VanHook
19 July 2011: ec197.
Cell shape asymmetries and oriented cell divisions shape epithelial tubes during morphogenesis. Abstract »  
Nancy R. Gough
19 July 2011: ec198.
R-spondins bind to the orphan GPCRs LGR4 and LGR5 to potentiate Wnt-β-catenin signaling. Abstract »  
John F. Foley
19 July 2011: ec199.
The recruitment of a subset of monocytes to metastatic sites promotes metastasis through the release of vascular endothelial growth factor. Abstract »  
Heather M. Thompson
19 July 2011: ec200.
Efficient recycling of an internalized G protein–coupled receptor involves the C terminus of c-Cbl. Abstract »  
Stella M. Hurtley
19 July 2011: ec201.
An optical bioprobe reveals action potential–like electrical spikes in individual bacteria. Abstract »  
Guy Riddihough
19 July 2011: ec202.
The structure of the ID complex reveals how phosphorylation and ubiquitination could influence its stability and DNA-binding functions. Abstract »  


Editorial Guides

Helena Mistry and Philip Toppin
19 July 2011: eg6.
Cells and society rely on information gatekeepers to identify problems and direct an appropriate response. Abstract »   Full Text »   PDF »  


Research Articles

Nagalingam R. Sundaresan, Vinodkumar B. Pillai, Don Wolfgeher, Sadhana Samant, Prabhakaran Vasudevan, Vishwas Parekh, Hariharasundaram Raghuraman, John M. Cunningham, Madhu Gupta, and Mahesh P. Gupta
19 July 2011: ra46.
Deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Juliet Mahtani-Patching, Joana F. Neves, Dick John Pang, Kostadin V. Stoenchev, Ana M. Aguirre-Blanco, Bruno Silva-Santos, and Daniel J. Pennington
19 July 2011: ra47.
T cell receptor chains lacking oligomerization domains can drive the development of early thymocyte progenitors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Chris Soon Heng Tan
19 July 2011: mr6.
Analysis of phosphorylation-based signaling systems provides insight into the evolution of these regulatory molecules. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882