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Editors' Choice

Wei Wong
26 July 2011: ec203.
Interferon production requires the activity of a prolyl isomerase on a kinase involved in Toll-like receptor signaling. Abstract »  
John F. Foley
26 July 2011: ec204.
An inhibitor of mitogen-activated protein kinase signaling in dendritic cells affects T cell differentiation. Abstract »  
Nancy R. Gough
26 July 2011: ec205.
An adhesion molecule may activate β-catenin signaling through a noncanonical pathway to promote cancer cell proliferation. Abstract »  
Heather M. Thompson
26 July 2011: ec206.
Bacterial ParA-like ATPases mediate cell cycle–dependent localization of chemotaxis proteins to cell poles. Abstract »  
Elizabeth M. Adler
26 July 2011: ec207.
The crystal structure of a voltage-gated sodium channel provides insight into its voltage-dependent gating, selectivity for sodium, and blockade by drugs. Abstract »  
Stella M. Hurtley
26 July 2011: ec208.
A bacterial pathogen reverses the modification of a host cell protein involved in membrane trafficking. Abstract »  
Valda Vinson
26 July 2011: ec209.
The structure of a eukaryotic pathogen adhesin bound to its receptor provides a basis for design of therapeutics. Abstract »  
Caroline Ash
26 July 2011: ec210.
Polymorphic receptors prevent cheaters from avoiding altruistic cell death in Dictyostelium. Abstract »  
Annalisa M. VanHook
26 July 2011: ec211.
MIEF1 promotes mitochondrial fusion despite recruiting the fission-promoting GTPase Drp1 to the mitochondrial membrane. Abstract »  



Sara A. Courtneidge and Annalisa M. VanHook
26 July 2011: pc14.
A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. Abstract »   Full Text »   Podcast »  


Research Articles

Brian T. Weinert, Sebastian A. Wagner, Heiko Horn, Peter Henriksen, Wenshe R. Liu, Jesper V. Olsen, Lars J. Jensen, and Chunaram Choudhary
26 July 2011: ra48.
Comparing the acetylomes with the phosphoproteomes of flies and humans suggests that phosphorylation sites may have evolved faster than did acetylation sites. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Manuela Quintavalle, Leonardo Elia, Jeffrey H. Price, Susanne Heynen-Genel, and Sara A. Courtneidge
26 July 2011: ra49.
Cyclin-dependent kinase 5 is identified as an anticancer target because its activity promotes invasiveness of cancer cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Elsa R. Flores and Georg Halder
26 July 2011: pe34.
α-Catenin inhibits the transcriptional coactivator Yap to limit epidermal stem cell proliferation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882