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Editors' Choice

John F. Foley
2 August 2011: ec212.
Deficiency in a Mg2+ transporter is associated with defective antigen receptor–dependent activation of phospholipase C {gamma}1 and Ca2+ flux in T cells. Abstract »  
Wei Wong
2 August 2011: ec213.
CaMKIIβ activity at the centrosome alters the subcellular localization of a ubiquitin ligase complex and promotes dendrite retraction. Abstract »  
Nancy R. Gough
2 August 2011: ec214.
Endocytosis is necessary for full activation of downstream signaling by the D1 dopamine receptor. Abstract »  
Elizabeth M. Adler
2 August 2011: ec215.
The aberrant activation and nuclear translocation of AMPK-α1 decreases Bcl2 abundance and contributes to neuronal death in Huntington’s disease. Abstract »  
Laura Zahn
2 August 2011: ec216.
An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome. Abstract »  
Heather M. Thompson
2 August 2011: ec217.
TRPV4 and RhoA signaling act upstream of pannexin 1 to mediate ATP release induced by osmotic cell swelling. Abstract »  
Peter R. Stern
2 August 2011: ec218.
Inducible neuron inhibition reveals essential roles for serotonergic neurons in respiratory and body temperature homeostasis. Abstract »  


Journal Club

Jason I. Herschkowitz and Xiaoyong Fu
2 August 2011: jc5.
Down-regulation of microRNAs associated with EGF signaling may contribute to tumor progression. Abstract »   Full Text »   PDF »  


Research Articles

Anand T. Vaidya, Chen-Hui Chen, Jay C. Dunlap, Jennifer J. Loros, and Brian R. Crane
2 August 2011: ra50.
Light-induced conformational changes in a blue-light sensor facilitate its dimerization. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Steve A. N. Goldstein
2 August 2011: pe35.
K2P potassium channels become permeable to Na+ with low extracellular K+ concentrations and may increase the risk for cardiac arrhythmias. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882