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Editors' Choice

Nancy R. Gough
9 August 2011: ec219.
An alternative splice variant in a TRPV channel allows vampire bats to detect the heat where blood flows in their prey. Abstract »  
Wei Wong
9 August 2011: ec220.
Anaplastic lymphoma kinase ensures continued signaling through growth-promoting pathways in the fly CNS during nutrient deprivation. Abstract »  
Elizabeth M. Adler
9 August 2011: ec221.
Apically secreted Hedgehog is internalized and recycled for secretion at the basolateral membrane and establishment of the long-range morphogenetic gradient. Abstract »  
Heather M. Thompson
9 August 2011: ec222.
Polarized cell protrusions promote localized induction of heart progenitor cells. Abstract »  
L. Bryan Ray
9 August 2011: ec223.
A molecule that functions in normal olfactory tract development could provide clues to failed neuronal regeneration in adults. Abstract »  


Editorial Guides

Nancy R. Gough
9 August 2011: eg7.
Signaling by GPCRs is encoded and decoded to produce ligand-specific, cell-specific, and genome-specific responses. Abstract »   Full Text »   PDF »  



Mark von Zastrow and Annalisa M. VanHook
9 August 2011: pc15.
Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. Abstract »   Full Text »   Podcast »  


Research Articles

Kelly N. Nobles, Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, Teng-Yi Huang, Erin A. Bressler, Makoto R. Hara, Sudha K. Shenoy, Steven P. Gygi, and Robert J. Lefkowitz
9 August 2011: ra51.
Different patterns of GPCR phosphorylation produce distinct conformations of β-arrestin and specific downstream responses. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Elaine K. Lau, Michelle Trester-Zedlitz, Jonathan C. Trinidad, Sarah J. Kotowski, Andrew N. Krutchinsky, Alma L. Burlingame, and Mark von Zastrow
9 August 2011: ra52.
Partial and full agonists of opioid receptors produce distinct responses by enriching distinct populations of phosphorylated receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Andrea Ahles, Francesca Rochais, Torsten Frambach, Moritz Bünemann, and Stefan Engelhardt
9 August 2011: ra53.
Variant forms of the β2-adrenergic receptor found in different individuals show distinct responses to repeated drug exposure. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Stephen B. Liggett
9 August 2011: pe36.
GRK-mediated phosphorylation patterns orchestrate GPCR signaling output. Abstract »   Full Text »   PDF »  
Paul A. Insel
9 August 2011: pe37.
The functional importance of the response of β2AR polymorphic variants to repeated stimulation will need to be demonstrated. Abstract »   Full Text »   PDF »  
Sang-Kyou Han and Melvin I. Simon
9 August 2011: pe38.
Signals underlying itch and pain emanating from the application of the same compound may be encoded by different receptors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882