ONLINE COVER This week features a Focus Issue that provides insight into signaling by G protein–coupled receptors (GPCRs), one of the largest and most extensively therapeutically targeted classes of receptors. Nobles et al. and Lau et al. describe how receptor phosphorylation enables agonists to trigger distinct cellular responses. Ahles et al. describe how mutations associated with disease affect receptor responsiveness to ligands. This research helps reveal how signaling by these receptors is encoded and decoded to produce ligand-specific, cell-specific, and genome-specific responses. The image shows an artist's rendition of receptor variation (circles in extracellular region) and phosphorylation sites (circles in the intracellular domain). [Image: Bricelyn Strauch, Science Signaling]

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