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Editors' Choice

Wei Wong
16 August 2011: ec224.
Survival signaling downstream of a neurotrophin receptor requires a ligand that can bind stably under acidic conditions. Abstract »  
Annalisa M. VanHook
16 August 2011: ec225.
Kif7 exerts both positive and negative control over hedgehog signaling through its regulation of Gli transcription factors. Abstract »  
Heather M. Thompson
16 August 2011: ec226.
Calcium triggers the nuclear translocation of the acyltransferase Lpcat1, where it mediates O-palmitoylation of histone H4. Abstract »  
Wei Wong
16 August 2011: ec227.
Stress activates p38α, which leads to enhanced surface abundance of a serotonin transporter and increased serotonin uptake. Abstract »  
Peter R. Stern
16 August 2011: ec228.
An important molecular mechanism involved in cognition has been unraveled. Abstract »  
Annalisa M. VanHook
16 August 2011: ec229.
Notch-mediated inhibition of the microRNA bantam helps to stabilize a compartment boundary by inhibiting cell proliferation and promoting actin polymerization. Abstract »  


Research Articles

Meng Jin, Beverly Errede, Marcelo Behar, Will Mather, Sujata Nayak, Jeff Hasty, Henrik G. Dohlman, and Timothy C. Elston
16 August 2011: ra54.
By reshaping the pheromone gradient through proteolysis, yeast find partners of the opposite "sex" for mating. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Susanna Stinson, Mark R. Lackner, Alex T. Adai, Nancy Yu, Hyo-Jin Kim, Carol O’Brien, Jill Spoerke, Suchit Jhunjhunwala, Zachary Boyd, Thomas Januario, Robert J. Newman, Peng Yue, Richard Bourgon, Zora Modrusan, Howard M. Stern, Søren Warming, Frederic J. de Sauvage, Lukas Amler, Ru-Fang Yeh, and David Dornan
16 August 2011: pt5.
MicroRNAs miR-221 and miR-222 are associated with a clinically aggressive form of breast cancer and promote epithelial-to-mesenchymal transition. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882