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Editors' Choice

Annalisa M. VanHook
30 August 2011: ec236.
Stress fibers promote nuclear accumulation of Yap, thus promoting proliferation. Abstract »  
Stella M. Hurtley
30 August 2011: ec237.
Interactions between adhesion molecules support the checkerboard-like patterning of cells in the cochlea. Abstract »  
Elizabeth M. Adler
30 August 2011: ec238.
Neuronal regulation of chaperone production in nematodes leads to differential responses to misfolded proteins under conditions of acute or chronic stress. Abstract »  
John F. Foley
30 August 2011: ec239.
The tumor suppressor protein Tsc1, an inhibitor of the mammalian target of rapamycin, is required to maintain naïve T cell quiescence. Abstract »  
Annalisa M. VanHook
30 August 2011: ec240.
ERK signaling alters flux through the tricarboxylic acid cycle to influence cell proliferation. Abstract »  
Paula A. Kiberstis
30 August 2011: ec241.
The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies. Abstract »  
Pamela J. Hines
30 August 2011: ec242.
Active transfer of a transcription factor between plant cells is required for stem cell maintenance. Abstract »  
Heather M. Thompson
30 August 2011: ec243.
SODD interacts with SKIP and represses its inositol polyphosphate 5-phosphatase activity. Abstract »  


Research Articles

Joanna C. Chan, Katherine M. Hannan, Kim Riddell, Pui Yee Ng, Abigail Peck, Rachel S. Lee, Sandy Hung, Megan V. Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E. Sheppard, Brian A. Hemmings, Michael N. Hall, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, and Richard B. Pearson
30 August 2011: ra56.
In addition to promoting translation, AKT also stimulates protein synthesis and cell growth by enhancing ribosome biogenesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Anutosh Chakraborty, Seyun Kim, and Solomon H. Snyder
30 August 2011: re1.
Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates. Gloss »   Abstract »   Full Text »   PDF »  



30 August 2011: er4.
The erroneous second and third pages of the four-page Fig. 4 are corrected. Full Text »   PDF »  



Jonathan Cooper, Wei Li, Liru You, Gaia Schiavon, Angela Pepe-Caprio, Lu Zhou, Ryohei Ishii, Marco Giovannini, C. Oliver Hanemann, Stephen B. Long, Hediye Erdjument-Bromage, Pengbo Zhou, Paul Tempst, and Filippo G. Giancotti
30 August 2011: pt6.
The closed conformer of Merlin inhibits tumorigenesis by inhibiting a ubiquitin ligase implicated in promoting cell cycle progression and inhibiting growth arrest, apoptosis, and adhesion. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882