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Editors' Choice

Wei Wong
6 September 2011: ec244.
A Legionella effector protein adds phosphocholine to Rab GTPases to manipulate membrane trafficking in host cells. Abstract »  
Elizabeth M. Adler
6 September 2011: ec245.
A phosphodiesterase 2A isoform acts in concert with soluble adenylyl cyclase to create a cyclic AMP signaling domain in the mitochondrial matrix. Abstract »  
Valda Vinson
6 September 2011: ec246.
A synthetic biomolecular circuit identifies abnormal cell states by the integration of multiple endogenous microRNA inputs. Abstract »  
Heather M. Thompson
6 September 2011: ec247.
A nongrowing tracheal system limits oxygen availability to internal tissues, thereby regulating molting cycles in insects. Abstract »  
L. Bryan Ray
6 September 2011: ec248.
A positive feedback loop in a biological oscillator allows effective setting of the clock by external cues. Abstract »  
Valda Vinson
6 September 2011: ec249.
Engineered ion channels enable manipulation of cellular function by selective chemical control of ionic conductance. Abstract »  


Editorial Guides

Nancy R. Gough
6 September 2011: eg8.
The month of September includes research, teaching materials, and methods that exemplify themes in computational and systems biology. Abstract »   Full Text »   PDF »  



Vineet Gupta and Annalisa M. VanHook
6 September 2011: pc17.
Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. Abstract »   Full Text »   Podcast »  


Research Articles

Dony Maiguel, Mohd Hafeez Faridi, Changli Wei, Yoshihiro Kuwano, Keir M. Balla, Dayami Hernandez, Constantinos J. Barth, Geanncarlo Lugo, Mary Donnelly, Ali Nayer, Luis F. Moita, Stephan Schürer, David Traver, Phillip Ruiz, Roberto I. Vazquez-Padron, Klaus Ley, Jochen Reiser, and Vineet Gupta
6 September 2011: ra57.
Drugs that activate integrins inhibit leukocyte recruitment to sites of inflammation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Robert J. Prill, Julio Saez-Rodriguez, Leonidas G. Alexopoulos, Peter K. Sorger, and Gustavo Stolovitzky
6 September 2011: mr7.
By aggregating the efforts of the research community, comprehensive and accurate inference of signaling networks may become achievable. Abstract »   Full Text »   PDF »  


Research Resources

Arunachalam Vinayagam, Ulrich Stelzl, Raphaele Foulle, Stephanie Plassmann, Martina Zenkner, Jan Timm, Heike E. Assmus, Miguel A. Andrade-Navarro, and Erich E. Wanker
6 September 2011: rs8.
Effective prediction of the direction of signal flow in an interaction network enables modeling of signaling dynamics and identification of regulatory proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882