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Editors' Choice

L. Bryan Ray
13 September 2011: ec250.
Reactive oxygen species produced by NADPH oxidase link mechanical stretching to calcium signaling in mammalian myocytes. Abstract »  
Nancy R. Gough
13 September 2011: ec251.
Quorum-sensing signaling triggers a morphogenic pathway enabling bacteria to produce gas vesicles to move by adaptive flotation. Abstract »  
John F. Foley
13 September 2011: ec252.
Astrocytes respond to single axon potentials and then enhance synaptic transmission in a calcium- and purinergic signaling–dependent mechanism. Abstract »  
Annalisa M. VanHook
13 September 2011: ec253.
An internal promoter drives expression of a truncated transcription factor that acts as a dominant-negative repressor of Wnt-responsive genes. Abstract »  
Elizabeth M. Adler
13 September 2011: ec254.
Thalamic neurons show constitutive nuclear localization of β-catenin. Abstract »  
Wei Wong
13 September 2011: ec255.
An amiloride-sensitive sodium channel transduces intense mechanical stimuli in Caenorhabditis elegans. Abstract »  
Pamela J. Hines
13 September 2011: ec256.
Postsynaptic plasticity participates in the adaptation of a sensory circuit to the environment. Abstract »  
Peter R. Stern
13 September 2011: ec257.
Action potential firing, initiated by HCN2 ion channels, is the basic mechanism underlying neuropathic pain. Abstract »  

 

Podcasts

Juan A. Recio and Annalisa M. VanHook
13 September 2011: pc18.
Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. Abstract »   Full Text »   Podcast »  

 

Research Articles

Pedro Andreu-Pérez, Rosaura Esteve-Puig, Carlos de Torre-Minguela, Marta López-Fauqued, Joan Josep Bech-Serra, Stephan Tenbaum, Elena R. García-Trevijano, Francesc Canals, Glenn Merlino, Matías A. Ávila, and Juan A. Recio
13 September 2011: ra58.
Arginine methylation of RAF proteins limits ERK activation after growth factor stimulation, thereby determining the biological response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jamie R. Schoenborn, Ying Xim Tan, Chao Zhang, Kevan M. Shokat, and Arthur Weiss
13 September 2011: ra59.
Signaling molecules downstream of the TCR are poised to rapidly respond to receptor activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Michael J. Clague
13 September 2011: pe40.
Endosomal recycling pathways dictate the signaling capacity of wild-type or mutant Met receptor. Abstract »   Full Text »   PDF »  

 

Teaching Resources

Eric A. Sobie, Young-Seon Lee, Sherry L. Jenkins, and Ravi Iyengar
13 September 2011: tr2.
This course introduces students to computational principles and approaches used in systems biology. Abstract »   Full Text »   PDF »  
Neil R. Clark and Avi Ma’ayan
13 September 2011: tr3.
Lecture notes, slides, and problem sets introduce the mathematical concepts behind principal components analysis. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Neil R. Clark and Avi Ma’ayan
13 September 2011: tr4.
Lecture materials and homework assignments illustrate the mathematical concepts behind gene-set enrichment analysis (GSEA). Abstract »   Full Text »   PDF »   Supplementary Materials »  
Avi Ma’ayan
13 September 2011: tr5.
Lecture notes, slides, and problem sets introduce applications of graph theory and network analysis in systems biology. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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