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Editors' Choice

Wei Wong
20 September 2011: ec258.
Prolonged adrenergic stimulation results in DNA damage through a β-arrestin1–dependent pathway. Abstract »  
Elizabeth M. Adler
20 September 2011: ec259.
CXCR7 heterodimerizes with CXCR4, leading to preferential activation of β-arrestin–mediated signaling pathways. Abstract »  
Nancy R. Gough
20 September 2011: ec260.
Mitochondrial calcium signals regulate mitochondrial motility. Abstract »  
Heather M. Thompson
20 September 2011: ec261.
Imatinib’s efficacy is mediated by directly inhibiting Kit and by indirectly relieving immunosuppression. Abstract »  
John F. Foley
20 September 2011: ec262.
The transmembrane protein Tim-3, which is associated with T cell exhaustion, enhances T cell receptor signaling pathways. Abstract »  
Heather M. Thompson
20 September 2011: ec263.
Activation of metalloproteinases by EphB–ephrin-B interactions alters cell affinity by inducing localized cleavage of E-cadherin. Abstract »  
Pamela J. Hines
20 September 2011: ec264.
Axons signal through both glutamate and adenosine triphosphate release to regulate their insulating wraps. Abstract »  
L. Bryan Ray
20 September 2011: ec265.
A receptor for gut hormones also functions in the brain, where its loss affects attention. Abstract »  



J. Silvio Gutkind and Annalisa M. VanHook
20 September 2011: pc19.
Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. Abstract »   Full Text »   Podcast »  


Research Articles

Hiroshi Yagi, Wenfu Tan, Patricia Dillenburg-Pilla, Sylvain Armando, Panomwat Amornphimoltham, May Simaan, Roberto Weigert, Alfredo A. Molinolo, Michel Bouvier, and J. Silvio Gutkind
20 September 2011: ra60.
Interfering with a specific G protein–coupled receptor pathway may provide a therapeutic approach to blocking metastasis of some forms of breast cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Damien Ramel, Frédéric Lagarrigue, Véronique Pons, Joëlle Mounier, Sophie Dupuis-Coronas, Gaëtan Chicanne, Philippe J. Sansonetti, Frédérique Gaits-Iacovoni, Hélène Tronchère, and Bernard Payrastre
20 September 2011: ra61.
Shigella keeps infected cells alive by preventing the lysosomal trafficking and degradation of an activated growth factor receptor. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Research Resources

Lindsay D. Rogers, Nat F. Brown, Yuan Fang, Steven Pelech, and Leonard J. Foster
20 September 2011: rs9.
The foodborne pathogen Salmonella triggers distinct phosphorylation events in host cells to promote infection. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Teaching Resources

Eric A. Sobie
20 September 2011: tr6.
Lecture notes, slides, and homework assignments illustrate a strategy for teaching. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Eric A. Sobie
20 September 2011: tr7.
By practicing with simple MATLAB scripts, students learn how to interact with this commonly used platform for performing computational analyses. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Susana R. Neves
20 September 2011: tr8.
These lecture materials describe how to create kinetic models based on information in the literature and include a student assignment. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882