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Editors' Choice

Nancy R. Gough
27 September 2011: ec266.
By infiltrating the epithelial layer, neutrophils cause damage but also stimulate repair. Abstract »  
John F. Foley
27 September 2011: ec267.
Activation of sphingosine 1-phosphate receptor 1 on endothelial cells suppresses the cytokine storm during influenza infection. Abstract »  
Elizabeth M. Adler
27 September 2011: ec268.
The increased presence of nanoclusters of oligomeric TCRs on memory cells may enable them to mount a more rapid and vigorous response. Abstract »  
Wei Wong
27 September 2011: ec269.
In response to food deprivation, ghrelin activates a positive feedback loop to elicit feeding behavior. Abstract »  
Heather M. Thompson
27 September 2011: ec270.
GRK5 promotes neurogenesis in a kinase-independent manner by linking actin bundles to the cell membrane. Abstract »  
Annalisa M. VanHook
27 September 2011: ec271.
ERK7 suppresses protein secretion in response to amino acid starvation. Abstract »  

 

Research Articles

Zineb Mounir, Jothi Latha Krishnamoorthy, Shuo Wang, Barbara Papadopoulou, Shirley Campbell, William J. Muller, Maria Hatzoglou, and Antonis E. Koromilas
27 September 2011: ra62.
Inhibition of a stress-response pathway renders tumor cells more susceptible to death induced by inhibitors of phosphoinositide 3-kinase signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Miquel Àngel Adrover, Zhike Zi, Alba Duch, Jörg Schaber, Alberto González-Novo, Javier Jimenez, Mariona Nadal-Ribelles, Josep Clotet, Edda Klipp, and Francesc Posas
27 September 2011: ra63.
The stress-activated protein kinase Hog1 delays bud morphogenesis and DNA replication through different cyclin proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Changsheng Lin, Jason Ear, Yelena Pavlova, Yash Mittal, Irina Kufareva, Majid Ghassemian, Ruben Abagyan, Mikel Garcia-Marcos, and Pradipta Ghosh
27 September 2011: ra64.
GIV links ligand stimulation of various receptors to downstream activation of a kinase involved in cell migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Teaching Resources

Kevin D. Costa, Steven H. Kleinstein, and Uri Hershberg
27 September 2011: tr9.
Lecture notes, slides, and problem set illustrate methods for curve fitting and error analysis relevant to development of computational models for biomedical applications. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Eric A. Sobie
27 September 2011: tr10.
Lecture notes, slides, and homework assignments illustrate a strategy for teaching mathematical treatments of biological bistability. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Eric A. Sobie
27 September 2011: tr11.
Lecture notes, slides, and homework assignments based on modeling the cell cycle are used to illustrate how simulations yield biological insight. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Susana R. Neves
27 September 2011: tr12.
Lecture notes, slides, and a student assignment illustrate a strategy for teaching mathematical modeling using the Virtual Cell environment. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Fernand Hayot
27 September 2011: tr13.
Lecture notes, slides, and a student assignment illustrate a strategy for teaching stochastic modeling of biological systems. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Lawrence Sirovich
27 September 2011: tr14.
Lecture notes, slides, and homework assignments illustrate a strategy for teaching methods for incorporating probability in the analysis of biological data. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882