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Editors' Choice

Elizabeth M. Adler
4 October 2011: ec272.
Hedgehog signaling mediates nociceptive sensitization in flies and influences morphine analgesia in rats. Abstract »  
Nancy R. Gough
4 October 2011: ec273.
Mitotic kinases converge at the mitochondria to promote fission and even distribution of mitochondria in dividing cells. Abstract »  
John F. Foley
4 October 2011: ec274.
Distinct cytoplasmic receptors detect specific pathogen-associated molecules to confer inflammasomes with ligand specificity. Abstract »  
L. Bryan Ray
4 October 2011: ec275.
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock. Abstract »  
Wei Wong
4 October 2011: ec276.
Gender differences in finger length ratios are caused by relative differences in sex hormone signaling in developing limb buds. Abstract »  
Peter R. Stern
4 October 2011: ec277.
An imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disturbances. Abstract »  
Stella M. Hurtley
4 October 2011: ec278.
A newly synthesized secretory protein quality control pathway is activated by direct binding of misfolded proteins to a sensor in the endoplasmic reticulum. Abstract »  
Valda K. Vinson
4 October 2011: ec279.
Directed protein evolution provides a series of fluorescent protein–based indicators for multicolor Ca2+ imaging. Abstract »  
Nancy R. Gough
4 October 2011: ec280.
Distinct functions of Yap1 in responding to stress are dictated by the abundance of its partner Ybp1. Abstract »  
Kristen L. Mueller
4 October 2011: ec281.
A molecular mechanism that allows lymphocytes to migrate against a chemokine gradient is revealed. Abstract »  



Andre Levchenko and Annalisa M. VanHook
4 October 2011: pc20.
By working together, cells can overcome the loss of information as it flows through a signaling network. Abstract »   Full Text »   Podcast »  


Research Articles

Eric M. Wexler, Ezra Rosen, Daning Lu, Gregory E. Osborn, Elizabeth Martin, Helen Raybould, and Daniel H. Geschwind
4 October 2011: ra65.
A systems biology approach identifies connections between Wnt1 signaling and neurodegenerative diseases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kentner L. Singleton, Monica Gosh, Radhika D. Dandekar, Byron B. Au-Yeung, Olga Ksionda, Victor L. J. Tybulewicz, Amnon Altman, Deborah J. Fowell, and Christoph Wülfing
4 October 2011: ra66.
Loss of the kinase Itk in activated T cells disrupts actin accumulation at the immunological synapse, compromising T cell activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Kazuhide Watanabe and Xing Dai
4 October 2011: pe41.
Wnt-stabilized β-catenin may enable embryonic stem cells to resist differentiation by balancing transcriptional repression and activation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882