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Editors' Choice

Nancy R. Gough
11 October 2011: ec282.
Insulin-like growth factor 2 contributes to fear extinction. Abstract »  
Elizabeth M. Adler
11 October 2011: ec283.
Saturated fatty acids promote redistribution of c-Src into detergent-resistant membrane fractions, thereby stimulating JNK activation. Abstract »  
Wei Wong
11 October 2011: ec284.
Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation. Abstract »  
Nancy R. Gough
11 October 2011: ec285.
Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action. Abstract »  
John F. Foley
11 October 2011: ec286.
Interleukin-37 protects against inflammatory bowel disease in mice by inhibiting the production of proinflammatory cytokines. Abstract »  
Kristen L. Mueller
11 October 2011: ec287.
Neurotransmitters relay immunosuppressive signals to T cells under pathological conditions. Abstract »  

 

Podcasts

Edward M. De Robertis and Annalisa M. VanHook
11 October 2011: pc21.
Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. Abstract »   Full Text »   Podcast »  

 

Research Articles

Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio
11 October 2011: ra67.
The presence of downstream partners that interact with enzymatically modified or unmodified signaling proteins changes the dynamics of signal transduction. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Edward Eivers, Hadrien Demagny, Renee H. Choi, and Edward M. De Robertis
11 October 2011: ra68.
The transcription factor Mad participates in two different developmentally important signaling pathways depending on its phosphorylation status. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Hyeilin Ham and Kim Orth
11 October 2011: pe42.
The reversible modification of a protein that regulates membrane trafficking promotes the replication of a bacterial pathogen. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882