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Editors' Choice

Elizabeth M. Adler
18 October 2011: ec288.
Inducible nitric oxide synthase in distinct cell types contributes to the pathogenesis of chronic obstructive pulmonary disease and pulmonary hypertension. Abstract »  
John F. Foley
18 October 2011: ec289.
A tumor-derived tryptophan metabolite activates the aryl hydrocarbon receptor in an autocrine and paracrine manner to promote tumor progression. Abstract »  
Valda K. Vinson
18 October 2011: ec290.
A synthetic circuit implementing density-controlled bacterial motility autonomously produces a tunable stripe pattern. Abstract »  
Kristen L. Mueller
18 October 2011: ec291.
Innate immune signaling and antimicrobial peptide activity maintain separation of the microbiota and intestinal epithelium. Abstract »  
Kristen L. Mueller
18 October 2011: ec292.
Commensal microflora promote the pathogenesis of mucosally acquired viruses. Abstract »  
Nancy R. Gough
18 October 2011: ec293.
By stimulating the production of an alternatively spliced antagonistic form of TRAIL, HIV-infected cells escape apoptotic death. Abstract »  
Wei Wong
18 October 2011: ec294.
Phosphorylation of a transcription factor induced by ER stress by p38 promotes glucose homeostasis. Abstract »  


Journal Club

Reina Aoki and Yun Rose Li
18 October 2011: jc6.
α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death. Abstract »   Full Text »   PDF »  


Research Articles

Shimpei Magori and Vitaly Citovsky
18 October 2011: ra69.
A plant pathogen prevents degradation of its key virulence factor in infected host cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Oscar Vadas, John E. Burke, Xuxiao Zhang, Alex Berndt, and Roger L. Williams
18 October 2011: re2.
The regulatory interactions between PI3Ks and their binding partners could be exploited for therapies. Gloss »   Abstract »   Full Text »   PDF »   Interactive Figures »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882