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Editors' Choice

John F. Foley
25 October 2011: ec295.
Loss of the kinase LRRK2 promotes the activity of the transcription factor NFAT, leading to enhanced inflammatory bowel disease. Abstract »  
Elizabeth M. Adler
25 October 2011: ec296.
Cyclin E contributes to synaptic plasticity and memory independent of its role in the cell cycle. Abstract »  
Wei Wong
25 October 2011: ec297.
A dioxygenase binds to and inhibits a hypoxia-inducible transcription factor in the presence of oxygen. Abstract »  
Valda K. Vinson
25 October 2011: ec298.
Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination. Abstract »  
Peter R. Stern
25 October 2011: ec299.
Paired bursting in coupled neurons depresses electrical synapses while their asymmetry increases after unidirectional use. Abstract »  
Caroline Ash
25 October 2011: ec300.
A beetle species synthesizes an antimicrobial peptide to constrain a bacterial symbiont in specialized organs. Abstract »  
L. Bryan Ray
25 October 2011: ec301.
Noise limits information transfer through a single signaling pathway in a single cell to just one bit. Abstract »  
Annalisa M. VanHook
25 October 2011: ec302.
A stochastically activated genetic circuit enables bacteria to respond to stress. Abstract »  


Editorial Guides

Nancy R. Gough
25 October 2011: eg9.
The latest research continues to add to the components and functions of the ERK mitogen-activated protein kinase signaling cascade. Abstract »   Full Text »   PDF »  



Adam A. Friedman, Norbert Perrimon, and Annalisa M. VanHook
25 October 2011: pc22.
A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. Abstract »   Full Text »   Podcast »  


Research Articles

Mei Xin, Yuri Kim, Lillian B. Sutherland, Xiaoxia Qi, John McAnally, Robert J. Schwartz, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson
25 October 2011: ra70.
A transcriptional coactivator in the Hippo pathway promotes cardiac growth. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Javier Rodríguez and Piero Crespo
25 October 2011: re3.
ERK2 plays kinase-independent roles in chromatin remodeling, gene transcription, and cell cycle regulation. Gloss »   Abstract »   Full Text »   PDF »  



Nir Yosef, Einat Zalckvar, Assaf D. Rubinstein, Max Homilius, Nir Atias, Liram Vardi, Igor Berman, Hadas Zur, Adi Kimchi, Eytan Ruppin, and Roded Sharan
25 October 2011: pl1.
Abstract »   Full Text »   PDF »   Supplementary Materials »  


Research Resources

Adam A. Friedman, George Tucker, Rohit Singh, Dong Yan, Arunachalam Vinayagam, Yanhui Hu, Richard Binari, Pengyu Hong, Xiaoyun Sun, Maura Porto, Svetlana Pacifico, Thilakam Murali, Russell L. Finley, Jr., John M. Asara, Bonnie Berger, and Norbert Perrimon
25 October 2011: rs10.
Interactome mapping and functional genomics in Drosophila reveal common and specific components of a mitogen-activated protein kinase pathway. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Scott M. Carlson, Candace R. Chouinard, Adam Labadorf, Carol J. Lam, Katrin Schmelzle, Ernest Fraenkel, and Forest M. White
25 October 2011: rs11.
A chemical genetics strategy identified 67 previously unknown substrates of the kinase ERK2, including the transcriptional repressor ETV3. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882