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Editors' Choice

John F. Foley
1 November 2011: ec303.
The adaptor protein STING, which mediates the interferon response to microbial DNA, also acts as a direct sensor of cyclic dinucleotides. Abstract »  
Elizabeth M. Adler
1 November 2011: ec304.
Activation of the aryl hydrocarbon receptor in intestinal lymphocytes by dietary components contributes to intestinal immune defenses. Abstract »  
Annalisa M. VanHook
1 November 2011: ec305.
The ubiquitin E3 ligase activity of BRCA1 is not required for tumor suppression. Abstract »  
Valda K. Vinson
1 November 2011: ec306.
Computational and experimental results provide support for defined protein folding pathways. Abstract »  
Paula A. Kiberstis
1 November 2011: ec307.
A specific set of circulating fatty acids triggers cardiac hypertrophy in snakes and mammals. Abstract »  
Wei Wong
1 November 2011: ec308.
Cytoplasmic Myc promotes antimycobacterial immune responses in macrophages. Abstract »  

 

Podcasts

Xiaoxia Li and Annalisa M. VanHook
1 November 2011: pc23.
An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. Abstract »   Full Text »   Podcast »  

 

Research Articles

Nam Hee Kim, Hyun Sil Kim, Nam-Gyun Kim, Inhan Lee, Hyung-Seok Choi, Xiao-Yan Li, Shi Eun Kang, So Young Cha, Joo Kyung Ryu, Jung Min Na, Changbum Park, Kunhong Kim, Sanghyuk Lee, Barry M. Gumbiner, Jong In Yook, and Stephen J. Weiss
1 November 2011: ra71.
The tumor suppressor p53 activates miRNA-34 to inhibit Wnt signaling and colorectal cancer cell invasiveness. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Caini Liu, Shadi Swaidani, Wen Qian, Zizhen Kang, Paige Sun, Yue Han, Chenhui Wang, Muhammet Fatih Gulen, Weiguo Yin, Chunjiang Zhang, Paul L. Fox, Mark Aronica, Thomas A. Hamilton, Saurav Misra, Junpeng Deng, and Xiaoxia Li
1 November 2011: ra72.
A cell-permeable peptide derived from an adaptor protein blocks cytokine receptor signaling and reduces inflammation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Peiqing Shi, Shu Zhu, Yingying Lin, Yongfeng Liu, Yan Liu, Zhijian Chen, Yufang Shi, and Youcun Qian
1 November 2011: ra73.
Persistent inflammation may be prevented by degradation of an adaptor protein required for inflammatory cytokine receptor signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Errata

 
1 November 2011: er5.
Errors in the labels of panels C and D of Fig. 7 and incorrect text callouts to Figs. 7E and 7F are corrected. Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882