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Editors' Choice

Nancy R. Gough
8 November 2011: ec309.
SHARPIN binds to the α subunit of integrins to attenuate activation. Abstract »  
Elizabeth M. Adler
8 November 2011: ec310.
Adenomatous polyposis coli determines the apical or basal site of cell extrusion from epithelia. Abstract »  
John F. Foley
8 November 2011: ec311.
Mammalian target of rapamycin complex 1 signaling in the uterus contributes to preterm birth in mice. Abstract »  
L. Bryan Ray
8 November 2011: ec312.
Cellular sensing of amino acids occurs at the lysosome and is mediated by the vacuolar proton pump. Abstract »  
Caroline Ash
8 November 2011: ec313.
Successful development of fruit flies depends on a gut bacterium that interacts with its host’s insulin-signaling pathway. Abstract »  
Stella M. Hurtley
8 November 2011: ec314.
Gentle exercise can ameliorate disease severity in a mouse model of a fatal neurodegenerative disease. Abstract »  
Stella M. Hurtley
8 November 2011: ec315.
Acetylation of an amino-terminal methionine is important for mediating specific protein-protein interactions. Abstract »  

 

Podcasts

David M. Sabatini and Annalisa M. VanHook
8 November 2011: pc24.
The vacuolar ATPase is required for amino acid–mediated activation of mTORC1. Abstract »   Full Text »   Podcast »  

 

Research Articles

Osamu Ishibashi, Md. Moksed Ali, Shan-Shun Luo, Takashi Ohba, Hidetaka Katabuchi, Toshiyuki Takeshita, and Toshihiro Takizawa
8 November 2011: ra74.
Short double-stranded RNAs induce death in certain cell types without knocking down gene expression. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Alexander Eichner and Michael Sixt
8 November 2011: pe43.
Desensitization of a sphingosine 1-phosphate receptor enables lymphocytes to leave the vascular compartment. Abstract »   Full Text »   PDF »  

 

Research Resources

Björn Hegemann, James R. A. Hutchins, Otto Hudecz, Maria Novatchkova, Jonathan Rameseder, Martina M. Sykora, Sihan Liu, Michael Mazanek, Péter Lénárt, Jean-Karim Hériché, Ina Poser, Norbert Kraut, Anthony A. Hyman, Michael B. Yaffe, Karl Mechtler, and Jan-Michael Peters
8 November 2011: rs12.
Analysis of the phosphorylation of mitotic protein complexes suggests that specific members of the complexes relay regulatory signals to these molecular machines. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882