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Editors' Choice

Wei Wong
22 November 2011: ec322.
The kinase Tao-1 promotes activation of the Hippo pathway. Abstract »  
Nancy R. Gough
22 November 2011: ec323.
In plants with sufficient oxygen, degradation by an N-end rule pathway destabilizes proteins that mediate the hypoxic gene program. Abstract »  
Elizabeth M. Adler
22 November 2011: ec324.
DISC1, a susceptibility gene for neuropsychiatric disorders, interacts with various partners to influence distinct aspects of neurodevelopment. Abstract »  
Annalisa M. VanHook
22 November 2011: ec325.
Neuropilins promote Hedgehog signaling by acting downstream of Smoothened. Abstract »  
John F. Foley
22 November 2011: ec326.
The anti-inflammatory protein A20 inhibits NF-{kappa}B signaling through a noncatalytic mechanism by binding to polyubiquitin chains. Abstract »  
Annalisa M. VanHook
22 November 2011: ec327.
Bacterial infection increases the fecundity of female fruit fly hosts by stimulating oocyte production. Abstract »  
Caroline Ash
22 November 2011: ec328.
During growth arrest, bacteria tolerate the presence of antibiotics thanks to mechanisms that protect against oxidant stress. Abstract »  
Caroline Ash
22 November 2011: ec329.
Sulfide formation helps to protect various bacteria from antibiotic toxicity. Abstract »  


Editorial Guides

Annalisa M. VanHook
22 November 2011: eg10.
The Hedgehog signaling cascade is regulated by a complex and diverse set of mechanisms. Abstract »   Full Text »   PDF »  


Research Articles

Michael P. Grant, Ann Stepanchick, Alice Cavanaugh, and Gerda E. Breitwieser
22 November 2011: ra78.
Activation of a G protein–coupled receptor increases its own surface abundance to enhance its signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Meital Gabay, Mary E. Pinter, Forrest A. Wright, PuiYee Chan, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, and Gregory G. Tall
22 November 2011: ra79.
Control of the insertion of G protein α subunits into endomembranes by Ric-8 proteins regulates the abundance and function of heterotrimeric G proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Thomas B. Kornberg
22 November 2011: pe44.
Cholesterol modification may alter the intracellular localization of Hedgehog, thereby influencing where Hedgehog is released. Abstract »   Full Text »   PDF »  



Ariel H. Polizio, Pilar Chinchilla, Xiaolen Chen, David R. Manning, and Natalia A. Riobo
22 November 2011: pt7.
Smoothened signals through small G proteins in one type of noncanonical Hedgehog signaling. Abstract »   Full Text »   PDF »   Slideshow »  
Sougata Roy and Thomas B. Kornberg
22 November 2011: pt8.
Cytonemes facilitate the formation of morphogen gradients by transferring signaling proteins from producing to receiving cells. Abstract »   Full Text »   PDF »   Slideshow »  
Ariel Ruiz i Altaba
22 November 2011: pt9.
Hedgehog signaling and the oncogenic load promote stem cell–like behavior and metastasis by influencing the balance between activator and repressor functions of Gli transcription factors. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882