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Cover Figure

ONLINE COVER This week, Science Signaling publishes a Focus Issue on the Hedgehog signaling pathway, which has critical roles in animal development, homeostasis, and disease. Articles in the Focus Issue and Archives describe how Hedgehog signaling is influenced by complex and diverse mechanisms, including ligand gradients, noncanonical signaling mechanisms, and combinatorial activities of repressor and activator forms of the Gli transcription factors. The image shows a model of trafficking and release for cholesterol-modified Hedgehog, which differs from that of Hedgehog not modified by cholesterol. [Image: Yana Hammond/Science Signaling]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882