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Editors' Choice

John F. Foley
29 November 2011: ec330.
Calcium signaling delays proapoptotic responses in cells stimulated through CD95. Abstract »  
Nancy R. Gough
29 November 2011: ec331.
Rhodopsin present in melanocytes contributes to a retinal-dependent rapid pigmentation response to ultraviolet light. Abstract »  
Wei Wong
29 November 2011: ec332.
Brassinosteroid signaling can be enhanced by BKI1, which is classically known as an inhibitor. Abstract »  
Paula A. Kiberstis
29 November 2011: ec333.
Neurons transplanted from healthy donor mice can repair brain circuitry and partially normalize metabolism in obese mice. Abstract »  
Peter R. Stern
29 November 2011: ec334.
Acute stress leads to reorganization of large-scale neural network connectivity in the brain that is driven by noradrenaline. Abstract »  
Paula A. Kiberstis
29 November 2011: ec335.
The mitochondrial state of a tumor cell prior to chemotherapy may help determine how well it responds to drug treatment. Abstract »  
Stella M. Hurtley
29 November 2011: ec336.
Patterning of Caenorhabditis elegans zygotes involves passive as well as active mechanisms. Abstract »  



Gerda E. Breitwieser and Annalisa M. VanHook
29 November 2011: pc25.
Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. Abstract »   Full Text »   Podcast »  


Research Articles

Giulia C. Minetti, Jerome N. Feige, Antonia Rosenstiel, Florian Bombard, Viktor Meier, Annick Werner, Frederic Bassilana, Andreas W. Sailer, Peter Kahle, Christian Lambert, David J. Glass, and Mara Fornaro
29 November 2011: ra80.
Signaling through Gαi2 induces hypertrophy and can counterbalance pathways that promote muscle wasting. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Leo M. Carlin, Rachel Evans, Hanna Milewicz, Luis Fernandes, Daniel R. Matthews, Michela Perani, James Levitt, Melanie D. Keppler, James Monypenny, Ton Coolen, Paul R. Barber, Borivoj Vojnovic, Klaus Suhling, Franca Fraternali, Simon Ameer-Beg, Peter J. Parker, N. Shaun B. Thomas, and Tony Ng
29 November 2011: ra81.
The oscillating activity of a cytoskeletal regulator enables natural killer cells to effectively perform their surveillance functions and polarize cytotoxic vesicles. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Denis C. Guttridge
29 November 2011: pe45.
i2 operates through multiple signaling pathways to stimulate maturation and growth of skeletal muscle fibers. Abstract »   Full Text »   PDF »  



Archana Joshi-Saha, Christiane Valon, and Jeffrey Leung
29 November 2011: re4.
Understanding how plants respond to the hormone abscisic acid provides targets for designing crops resilient to drought. Gloss »   Abstract »   Full Text »   PDF »  


Research Resources

Hirokazu Okada, Akiyoshi Uezu, Frank M. Mason, Erik J. Soderblom, M. Arthur Moseley, III, and Scott H. Soderling
29 November 2011: rs13.
Domain-based proteomics analysis identifies binding partners and potential functions for a family of GTPase-activating proteins that regulate the cytoskeleton. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882