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Cover Figure

ONLINE COVER This week features a Research Article describing the analysis of the SH2 domain–containing proteins in 21 species, which provides insight into the evolution of modular protein domains and organismal complexity. The image is an artist's rendition of how the number of SH2 domain–containing proteins increases with organismal complexity. [Image: Sophia J. Lee, freelance artist]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882