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Editors' Choice

Nancy R. Gough
6 December 2011: ec337.
Pyruvate kinase M2 interacts with nuclear β-catenin to promote cell proliferation. Abstract »  
L. Bryan Ray
6 December 2011: ec338.
The glycolytic metabolism of cancers differs from normal tissues, allowing tumor cells to survive under oxidative stress. Abstract »  
Elizabeth M. Adler
6 December 2011: ec339.
Variations in the vasopressin-1A receptor combine with stress level and gender to affect sensitivity to pain. Abstract »  
Kristen L. Mueller
6 December 2011: ec340.
Epidermal abrasion and T cells in the skin work together to drive the type of immune responses seen in allergy and asthma. Abstract »  
Nancy R. Gough
6 December 2011: ec341.
Peroxide oxidizes and activates the kinase Lyn to recruit neutrophils to the site of injury. Abstract »  
Wei Wong
6 December 2011: ec342.
The effectiveness of antipsychotics may be related to their effect on signaling through a GPCR heteromer. Abstract »  


Editorial Guides

Michael B. Yaffe
6 December 2011: eg11.
Computational biology studies are complex; papers describing the results should not be. Abstract »   Full Text »   PDF »  


Research Articles

Katrin Deinhardt, Taeho Kim, Daniel S. Spellman, Richard E. Mains, Betty A. Eipper, Thomas A. Neubert, Moses V. Chao, and Barbara L. Hempstead
6 December 2011: ra82.
Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Bernard A. Liu, Eshana Shah, Karl Jablonowski, Andrew Stergachis, Brett Engelmann, and Piers D. Nash
6 December 2011: ra83.
Analysis of SH2 domain–containing proteins provides insights into the evolution of modular protein domains and organismal complexity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Guo Fu, Jianfang Hu, Nathalie Niederberger-Magnenat, Vasily Rybakin, Javier Casas, Pia P. Yachi, Stephanie Feldstein, Bo Ma, John A. H. Hoerter, Jeanette Ampudia, Stephanie Rigaud, Florence Lambolez, Amanda L. Gavin, Karsten Sauer, Hilde Cheroutre, and Nicholas R. J. Gascoigne
6 December 2011: ra84.
Studies of knockout mice delineate specific and overlapping roles for different protein kinase C isoforms in T cell biology. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Takashi Tanaka, Yu Yamamoto, Ryuta Muromoto, Osamu Ikeda, Yuichi Sekine, Michael J. Grusby, Tsuneyasu Kaisho, and Tadashi Matsuda
6 December 2011: ra85.
An E3 ubiquitin ligase inhibits the development of inflammatory T cells involved in autoimmune diseases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882