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Editors' Choice

Elizabeth M. Adler
13 December 2011: ec343.
Aldosterone promotes postinfarction cardiac rupture through the oxidation of the kinase CaMKII. Abstract »  
Wei Wong
13 December 2011: ec344.
Cleavage of the deubiquitinase CYLD by caspase 8 prevents necrosis in response to the cytokine TNF. Abstract »  
Nancy R. Gough
13 December 2011: ec345.
Larval fly neurons degenerate and produce a signal that directs the adult neurons where to migrate. Abstract »  
L. Bryan Ray
13 December 2011: ec346.
Low-affinity nutrient transporters sense depletion earlier than high-affinity transporters, thus preparing cells for starvation. Abstract »  
Pamela J. Hines
13 December 2011: ec347.
Coordination of different defense pathways across cell compartments produces a fully effective innate immune response. Abstract »  
John F. Foley
13 December 2011: ec348.
Receptor-like tyrosine phosphatases have opposing roles in regulating chemoattractant receptor signaling in mouse neutrophils. Abstract »  


Research Articles

Navasona Krishnan, Cexiong Fu, Darryl J. Pappin, and Nicholas K. Tonks
13 December 2011: ra86.
Reversible inactivation by sulfhydration of the protein tyrosine phosphatase PTP1B activates the kinase PERK to promote the ER stress response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Tasuku Ueno, Björn H. Falkenburger, Christopher Pohlmeyer, and Takanari Inoue
13 December 2011: ra87.
The ability of phosphoinositides to produce functionally diverse effects may depend on the relative concentrations of different species. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Angela E. Douglas
13 December 2011: pe46.
Gut microbiota in Drosophila promote metabolic signaling pathways, resulting in increased growth and development rates. Abstract »   Full Text »   PDF »  



Xiaoyong Liu and François Fagotto
13 December 2011: pl2.
A semipermeabilization step and a specific Percoll gradient composition enable effective cellular fractionation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882