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Editors' Choice

Wei Wong
20 December 2011: ec349.
A kinase involved in detecting viral RNA also enhances inhibitory neurotransmission in the brain. Abstract »  
Kristen L. Mueller
20 December 2011: ec350.
Nutrients can shape immune system development function through aryl hydrocarbon receptor signaling. Abstract »  
L. Bryan Ray
20 December 2011: ec351.
The release of adenosine triphosphate through autophagy can promote antitumor immune responses. Abstract »  
John F. Foley
20 December 2011: ec352.
Complement factor C3a and its receptor are required for the mutual attraction and collective migration of neural crest cells. Abstract »  
Nancy R. Gough
20 December 2011: ec353.
The C-terminal domain of a bacterial response regulator insulates the protein from inappropriate activation by phosphodonor metabolites. Abstract »  
Sacha Vignieri
20 December 2011: ec354.
Life in a high–carbon dioxide environment has eliminated acid-evoked pain in the naked mole-rat. Abstract »  
Nancy R. Gough
20 December 2011: ec355.
Eukaryotic translation initiation factor 3 subunit a (eIF3a) interacts with the mitogen-activated protein kinase kinase kinase Raf-1 and prevents its activation. Abstract »  
Peter R. Stern
20 December 2011: ec356.
Transmitter release at the fly neuromuscular junction is abolished in the absence of a scaffold protein. Abstract »  



Peter H. Krammer and Annalisa M. VanHook
20 December 2011: pc26.
Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. Abstract »   Full Text »   Podcast »  


Research Articles

Yuan-Yuan Zhang, Jia-Wei Wu, and Zhi-Xin Wang
20 December 2011: ra88.
Identification of the mechanism through which the kinase p38α interacts with the phosphatase that inactivates it could lead to the development of more specific anti-inflammatory drugs. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Daniel Mariappa, Kathrin Sauert, Karina Mariño, Daniel Turnock, Ryan Webster, Daan M. F. van Aalten, Michael A. J. Ferguson, and H.-Arno J. Müller
20 December 2011: ra89.
Fibroblast growth factor signaling is connected to metabolism through the intracellular O-GlcNAcylation of the receptor complex. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Angelika Schmidt, Nina Oberle, Eva-Maria Weiß, Diana Vobis, Stefan Frischbutter, Ria Baumgrass, Christine S. Falk, Mathias Haag, Britta Brügger, Hongying Lin, Georg W. Mayr, Peter Reichardt, Matthias Gunzer, Elisabeth Suri-Payer, and Peter H. Krammer
20 December 2011: ra90.
Inhibition of calcium signaling is critical for the suppression of T cell responses by regulatory T cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Elizabeth J. Goldsmith
20 December 2011: pe47.
Structural analysis reveals the mode of interaction between a mitogen-activated protein kinase and its inactivating phosphatase. Abstract »   Full Text »   PDF »  



Christoph H. Emmerich, Anna C. Schmukle, and Henning Walczak
20 December 2011: re5.
Linear ubiquitin chains transmit signals that are induced by diverse stimuli and regulate cell activation and death. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882