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Editors' Choice

Wei Wong
3 January 2012: ec1.
Components of the circadian clock repress transcription of metabolic genes by the glucocorticoid receptor. Abstract »  
John F. Foley
3 January 2012: ec2.
The transcription factor Myc controls the metabolic changes required for the proliferation of activated T cells. Abstract »  
Nancy R. Gough
3 January 2012: ec3.
Phosphorylation by IKK{varepsilon} of the transcription factor STAT1 tips the balance of the antiviral response from type II to type I interferon. Abstract »  
Elizabeth M. Adler
3 January 2012: ec4.
Albumin modulates the abundance and activity of renal Na,K-ATPase. Abstract »  
Annalisa M. VanHook
3 January 2012: ec5.
Lipid modification of Wnt ligands is required for their Wntless-mediated secretion. Abstract »  
Kristen L. Mueller
3 January 2012: ec6.
Hedgehog signaling is required for maintaining the integrity of the blood-brain barrier. Abstract »  
Nancy R. Gough
3 January 2012: ec7.
Mutant K-Ras stimulates apoptosis unless countered by wild-type K-Ras. Abstract »  
Stella M. Hurtley
3 January 2012: ec8.
A protein involved in redox signaling disassembles actin filaments and alters their reassembly. Abstract »  
Peter R. Stern
3 January 2012: ec9.
A transcription factor dependent on electrical activity regulates genes involved in long-term memory formation. Abstract »  


Editorial Guides

Elizabeth M. Adler
3 January 2012: eg1.
Signaling breakthroughs in 2011 involved structural analyses of signaling proteins, technological advances in imaging, and insights into the mechanisms controlling gene expression, immune function, and the cellular response to stress. Abstract »   Full Text »   PDF »  



Ronny Straube
3 January 2012: lc1.
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio
3 January 2012: lc2.
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states. Abstract »   Full Text »   PDF »  


Research Articles

Delphine Cougot, Eric Allemand, Lise Rivière, Shirine Benhenda, Karine Duroure, Florence Levillayer, Christian Muchardt, Marie-Annick Buendia, and Christine Neuveut
3 January 2012: ra1.
A virus prolongs the activity of a host transcription factor to promote expression of viral genes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kosuke Takeda, Danying Shao, Micha Adler, Pascale G. Charest, William F. Loomis, Herbert Levine, Alex Groisman, Wouter-Jan Rappel, and Richard A. Firtel
3 January 2012: ra2.
Rapid adaptation to changes in chemoattractant concentration involves an incoherent feedforward structure of the underlying signaling network. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882