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ONLINE COVER This week features the annual Signaling Breakthroughs of the Year Editorial Guide that highlights advances in cell signaling selected from research nominated by the Board of Reviewing Editors. This edition includes breakthroughs in the structural analysis of signaling proteins, technological advances in imaging, and insights into the mechanisms controlling gene expression, immune function, and the cellular response to stress. The image is an artist's rendition of the advances in imaging that can be achieved using fluorescent probes of various colors. [Image: Yana Hammond/Science Signaling]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882