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Editors' Choice

Wei Wong
10 January 2012: ec10.
The transporter for an endocannabinoid is a catalytically inactive form of an enzyme that degrades the endocannabinoid. Abstract »  
Stella M. Hurtley
10 January 2012: ec11.
Lack of the transporter critical for recycling of nucleosides after phagocytosis results in a fatal expansion of macrophages. Abstract »  
Annalisa M. VanHook
10 January 2012: ec12.
An adaptor protein opposes integrin signaling to promote cofilin signaling and thereby directed cell migration. Abstract »  
Pamela J. Hines
10 January 2012: ec13.
Two players and one chair regulate this plant hormone signaling cascade. Abstract »  
Nancy R. Gough
10 January 2012: ec14.
Brassinosteroid signaling can either enhance or attenuate the plant’s response to infection. Abstract »  
John F. Foley
10 January 2012: ec15.
Acetylation of rictor, an adaptor protein in mTORC2, stimulates the phosphorylation and activation of Akt. Abstract »  
Stella M. Hurtley
10 January 2012: ec16.
A bifunctional enzyme adds a heteropolysaccharide to an extracellular matrix receptor, enabling it to bind laminin. Abstract »  


Editorial Guides

Nancy R. Gough
10 January 2012: eg2.
Research reveals new functions for Wnt in cancer, tooth development, and neuronal pathfinding. Abstract »   Full Text »   PDF »  



Travis L. Biechele, Andy J. Chien, Randall T. Moon, and Annalisa M. VanHook
10 January 2012: pc1.
Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. Abstract »   Full Text »   Podcast »  


Research Articles

Travis L. Biechele, Rima M. Kulikauskas, Rachel A. Toroni, Olivia M. Lucero, Reyna D. Swift, Richard G. James, Nick C. Robin, David W. Dawson, Randall T. Moon, and Andy J. Chien
10 January 2012: ra3.
The functional crosstalk between Wnt/β-catenin and BRAF signaling may yield more effective therapies for treating melanoma. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Daniel J. O’Connell, Joshua W. K. Ho, Tadanori Mammoto, Annick Turbe-Doan, Joyce T. O’Connell, Psalm S. Haseley, Samuel Koo, Nobuhiro Kamiya, Donald E. Ingber, Peter J. Park, and Richard L. Maas
10 January 2012: ra4.
Computational and genetic analyses reveal a key circuit involving Wnt and Bmp in developing teeth in mice. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Katrin Luckert, Taranjit S. Gujral, Marina Chan, Mark Sevecka, Thomas O. Joos, Peter K. Sorger, Gavin MacBeath, and Oliver Pötz
10 January 2012: pl1.
Combining two strategies enables simultaneous quantification of multiple signaling proteins. Abstract »   Full Text »   PDF »  



B. Ian Hutchins, Li Li, and Katherine Kalil
10 January 2012: pt1.
Wnt-mediated axon repulsion requires the calcium- and calmodulin-dependent protein kinase II. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882