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Cover Figure

ONLINE COVER This week features a Research Article that suggests that release of the cytokine interleukin-11 from dying hepatocytes in response to oxidative stress stimulates the compensatory proliferation of surrounding cells to maintain tissue homeostasis. The image shows dying hepatocytes surrounding the central vein in the liver of a mouse treated with the drug acetaminophen. [Image: Takashi Nishina and Hiroyasu Nakano, Juntendo University School of Medicine, Tokyo, Japan]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882