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Editors' Choice

Nancy R. Gough
17 January 2012: ec17.
The Nedd4 ubiquitin ligase adaptor Ndfip1 is needed for nuclear translocation of the lipid phosphatase Pten after cerebral ischemia. Abstract »  
John F. Foley
17 January 2012: ec18.
Cocaine promotes the nuclear accumulation of histone deacetylase 5, which limits the rewarding effect of the drug. Abstract »  
Peter R. Stern
17 January 2012: ec19.
Opioid administration turns down a pain amplifier by reversing synaptic long-term potentiation in spinal nociceptive pathways. Abstract »  
Wei Wong
17 January 2012: ec20.
Methylation of two adaptor proteins by a bacterial effector protein prevents activation of the NF-{kappa}B pathway. Abstract »  
Kristen L. Mueller
17 January 2012: ec21.
A pseudoprotease is required for the proteolytic cleavage of the proinflammatory cytokine tumor necrosis factor. Abstract »  
Annalisa M. VanHook
17 January 2012: ec22.
Wnt signaling is required for proper formation of motile cilia in zebrafish. Abstract »  
Elizabeth M. Adler
17 January 2012: ec23.
Exosomal secretion of microRNAs from noncancerous cells can inhibit cancer cell proliferation. Abstract »  
Stella M. Hurtley
17 January 2012: ec24.
An evolutionarily conserved Ca2+-binding protein promotes parasite invasion. Abstract »  
Guy Riddihough
17 January 2012: ec25.
A fluoride-sensing riboswitch regulates the expression of putative fluoride channels in prokaryotes. Abstract »  


Research Articles

Takashi Nishina, Sachiko Komazawa-Sakon, Saeko Yanaka, Xuehua Piao, Dong-Mei Zheng, Jiang-Hu Piao, Yuko Kojima, Shunhei Yamashina, Emiko Sano, Tracy Putoczki, Takahiro Doi, Takashi Ueno, Junji Ezaki, Hiroko Ushio, Matthias Ernst, Kouhei Tsumoto, Ko Okumura, and Hiroyasu Nakano
17 January 2012: ra5.
In dying cells, reactive oxygen species stimulate the production of a cytokine that triggers the healthy neighboring cells to proliferate. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yuxiao Wang, Huawei He, Nishi Srivastava, Sheikh Vikarunnessa, Yong-bin Chen, Jin Jiang, Christopher W. Cowan, and Xuewu Zhang
17 January 2012: ra6.
Semaphorin-mediated growth cone collapse may result from the GTPase-activating protein activity of dimerized plexin receptors for Rap. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Amin S. Ghabrial
17 January 2012: pe1.
Signaling through the fibroblast growth factor receptors Heartless and Breathless requires O-GlcNAcylation of an adaptor protein. Abstract »   Full Text »   PDF »  
Patrick A. Lewis and Claudia Manzoni
17 January 2012: pe2.
The kinase LRRK2 is genetically linked to diverse pathologies, including Parkinson’s and Crohn’s diseases. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882