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Editors' Choice

Nancy R. Gough
24 January 2012: ec26.
Sulfydration of a subunit of NF-{kappa}B promotes its interaction with a coactivator and stimulates production of genes encoding antiapoptotic proteins. Abstract »  
Elizabeth M. Adler
24 January 2012: ec27.
Insulin switches pancreatic acinar cells to a primarily glycolytic metabolism under conditions of oxidative stress, allowing them to maintain ATP production. Abstract »  
John F. Foley
24 January 2012: ec28.
The increased membrane tension at the leading edge of a migrating cell maintains cell polarity. Abstract »  
Paula A. Kiberstis
24 January 2012: ec29.
An RNA interference screen identifies a "druggable" enzyme whose inhibition halts tumor cell growth. Abstract »  
Peter R. Stern
24 January 2012: ec30.
The computational power of individual neurons is determined by a surprisingly precise wiring of neuronal networks. Abstract »  
Kristen L. Mueller
24 January 2012: ec31.
Cell-fate decisions in activated B lymphocytes are determined by stochastic competition. Abstract »  
Kristen L. Mueller
24 January 2012: ec32.
The activating receptor NKp46 is important for keeping the responses of natural killer cells in check. Abstract »  

 

Research Articles

Christine L. Gee, Kadamba G. Papavinasasundaram, Sloane R. Blair, Christina E. Baer, Arnold M. Falick, David S. King, Jennifer E. Griffin, Harene Venghatakrishnan, Andrew Zukauskas, Jun-Rong Wei, Rakesh K. Dhiman, Dean C. Crick, Eric J. Rubin, Christopher M. Sassetti, and Tom Alber
24 January 2012: ra7.
Structure-function studies in mycobacteria reveal how a Ser-Thr protein kinase and pseudokinase work together to regulate the synthesis of the bacterial cell wall. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Arnulfo Torres, Fushun Wang, Qiwu Xu, Takumi Fujita, Radoslaw Dobrowolski, Klaus Willecke, Takahiro Takano, and Maiken Nedergaard
24 January 2012: ra8.
Local decreases in extracellular calcium trigger signaling events in astrocytes that activate inhibitory neurotransmission. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Digby F. Warner and Valerie Mizrahi
24 January 2012: pe3.
A serine-threonine kinase targets a pseudokinase to control the synthesis of the cell wall of the bacterium that causes tuberculosis. Abstract »   Full Text »   PDF »  
Dmitri A. Rusakov
24 January 2012: pe4.
Reduced extracellular calcium stimulates astrocytes to release adenosine triphosphate, which activates inhibitory neurons and may limit excitability. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882