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Editors' Choice

Elizabeth M. Adler
7 February 2012: ec40.
Resveratrol acts as a competitive phosphodiesterase inhibitor to initiate pathways that mediate its beneficial effects on metabolic disorders. Abstract »  
Kristen L. Mueller
7 February 2012: ec41.
A specialized population of B lymphocytes is important for controlling bacterial infections and preventing sepsis. Abstract »  
John F. Foley
7 February 2012: ec42.
Temporal analysis of individual activated T cells reveals programs of sequential secretion of multiple effector cytokines. Abstract »  
Wei Wong
7 February 2012: ec43.
By altering the transcriptional response to Notch signaling, the transcription factor Hamlet enables Notch to specify diverse cell fates. Abstract »  
Annalisa M. VanHook
7 February 2012: ec44.
Biochemistry and genetics reveal the identity of specific ligand-receptor pairs that affect stomatal development. Abstract »  
Annalisa M. VanHook
7 February 2012: ec45.
Sequential interactions of Notch and Wnt signaling are required for segregation of mesoderm and endoderm in the sea urchin embryo. Abstract »  
Laura Zahn
7 February 2012: ec46.
Resistance to avermectin, an antinematode drug, is conferred by a deletion in a glutamate-gated chloride channel. Abstract »  



Kathryn M. Taylor and Annalisa M. VanHook
7 February 2012: pc3.
Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Abstract »   Full Text »   Podcast »  


Research Articles

Kathryn M. Taylor, Stephen Hiscox, Robert I. Nicholson, Christer Hogstrand, and Peter Kille
7 February 2012: ra11.
Phosphorylation of the zinc channel ZIP7 releases zinc from the endoplasmic reticulum and promotes signals associated with proliferation and migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
C. Henrique Serezani, Steve Kane, Alexandra I. Medeiros, Ashley M. Cornett, Sang-Hoon Kim, Mariana Morato Marques, Sang-Pyo Lee, Casey Lewis, Emilie Bourdonnay, Megan N. Ballinger, Eric S. White, and Marc Peters-Golden
7 February 2012: ra12.
By promoting actin depolymerization, the protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



David J. Eide
7 February 2012: pe5.
The presence of low- and high-affinity transporters enables cells to adequately prepare for nutrient fluctuations. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882