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Editors' Choice

Valda Vinson
14 February 2012: ec47.
Details are revealed as to how cyclic adenosine monophosphate (cAMP) binding causes dissociation and activation of cAMP-dependent protein kinase. Abstract »  
Nancy R. Gough
14 February 2012: ec48.
The transcription factor NFAT converts a short calcium signal into a long-term, all-or-none gene expression response. Abstract »  
Valda Vinson
14 February 2012: ec49.
The arrangement of four central ion-binding sites with differing specificities suggests how a membrane transporter protein works. Abstract »  
Peter R. Stern
14 February 2012: ec50.
Protein synthesis underlying olfactory memory storage takes place outside the mushroom body—the site of memory storage. Abstract »  
Kristen L. Mueller
14 February 2012: ec51.
Maintenance of T cell tolerance is likely regulated by epigenetic mechanisms. Abstract »  
John F. Foley
14 February 2012: ec52.
An RNAi-based screen reveals that the energy-sensing protein AMPK is acetylated by p300 and deacetylated by HDAC1. Abstract »  
Wei Wong
14 February 2012: ec53.
The type 5 phosphodiesterase inhibitor Levitra (vardenafil) prevents noise-induced hearing loss in rats. Abstract »  



Marc Peters-Golden and Annalisa M. VanHook
14 February 2012: pc4.
The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. Abstract »   Full Text »   Podcast »  


Research Articles

William S. Bowen, Laurie A. Minns, David A. Johnson, Thomas C. Mitchell, Melinda M. Hutton, and Jay T. Evans
14 February 2012: ra13.
A single change in a synthetic lipid A mimetic may reduce the toxicity of this vaccine adjuvant. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Shou-Ih Hu, Mark Katz, Sherry Chin, Xiaoqing Qi, Joseph Cruz, Chikwendu Ibebunjo, Shanchuan Zhao, Amy Chen, and David J. Glass
14 February 2012: ra14.
In muscle, the kinase-dependent and -independent functions of MNK2 inhibit the protein translation protein eIF4G under conditions that promote atrophy. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Teaching Resources

Joseph D. Bartho, Kien Ly, and Debbie L. Hay
14 February 2012: tr1.
Students measure the changes in cyclic AMP, a second messenger molecule, with a light-based assay. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882