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Editors' Choice

John F. Foley
21 February 2012: ec54.
The exposure of host sugar molecules from damaged intracellular vesicles containing bacteria stimulates an autophagic response to combat infection. Abstract »  
Nancy R. Gough
21 February 2012: ec55.
The receptor LRP2 appears to deliver the morphogen Sonic hedgehog to its receptor Patched to enable proper specification of the ventral forebrain. Abstract »  
Valda Vinson
21 February 2012: ec56.
Octopus potassium channels function efficiently at different temperatures due to RNA editing and not genetic differences. Abstract »  
Wei Wong
21 February 2012: ec57.
Inhibiting protein kinase A in locusts attenuates the acquisition of gregarious behavior, which is required for swarming. Abstract »  
Annalisa M. VanHook
21 February 2012: ec58.
Poly(ADP-ribosyl)ation may recruit ubiquitin E3 ligases to target proteins. Abstract »  
Valda Vinson
21 February 2012: ec59.
A channel in a lipid-dependent GPCR allows ligand to access its binding site from within the plasma membrane. Abstract »  
Nancy R. Gough
21 February 2012: ec60.
Without PTEN to restrain Akt activity, Notch signaling is inhibited and neural progenitor cells become depleted. Abstract »  
Caroline Ash
21 February 2012: ec61.
Expression of nitric oxide synthase followed by peroxidase activity makes Plasmodium visible to the insect’s complement system. Abstract »  
Kristen L. Mueller
21 February 2012: ec62.
Bacterially derived flagellin binds to an innate immune receptor to form a tail-to-tail heterodimeric signaling complex. Abstract »  
Phillip Szuromi
21 February 2012: ec63.
Cargoes stored in folded DNA origami are released when aptamers in the structure bind target protein molecules. Abstract »  

 

Research Articles

Huai-hu Chuang and Alexander Y. Chuang
21 February 2012: ra15.
Opposing actions of RGS proteins both stimulate and inhibit G proteins to modulate the amplitude and kinetics of the downstream response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yang Sun, Chenggang Li, Yuelong Shu, Xiangwu Ju, Zhen Zou, Hongliang Wang, Shuan Rao, Feng Guo, Haolin Liu, Wenlong Nan, Yan Zhao, Yiwu Yan, Jun Tang, Chen Zhao, Peng Yang, Kangtai Liu, Shunxin Wang, Huijun Lu, Xiao Li, Lei Tan, Rongbao Gao, Jingdong Song, Xiang Gao, Xinlun Tian, Yingzhi Qin, Kai-Feng Xu, Dangsheng Li, Ningyi Jin, and Chengyu Jiang
21 February 2012: ra16.
Blocking autophagy reduces the extent of lung damage and decreases mortality in mice infected with the H5N1 strain of avian influenza. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Johannes L. Bos and Willem-Jan Pannekoek
21 February 2012: pe6.
Semaphorin binding stimulates the ability of plexin receptors to inhibit the GTPase Rap1, thereby enabling neurite retraction. Abstract »   Full Text »   PDF »  

 

Errata

 
21 February 2012: er1.
Two misleading or scientifically inaccurate statements were made, one in the abstract and one in the main text. Full Text »   PDF »  

 

Presentations

Peter ten Dijke, Anastasia D. Egorova, Marie-José T. H. Goumans, Robert E. Poelmann, and Beerend P. Hierck
21 February 2012: pt2.
The loss of primary cilia is a prerequisite for flow-induced endothelial-to-mesenchymal transition in heart development. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882