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Editors' Choice

Wei Wong
28 February 2012: ec64.
Fructose activates sweet taste receptors in β cells to promote glucose-stimulated insulin secretion. Abstract »  
Nancy R. Gough
28 February 2012: ec65.
A lipid-binding protein in yeast integrates lipid and amino acid metabolism to establish growth or quiescence as appropriate. Abstract »  
John F. Foley
28 February 2012: ec66.
Circadian control of the abundance of Toll-like receptor 9 regulates innate and adaptive immune responses. Abstract »  
Kristen L. Mueller
28 February 2012: ec67.
A danger signal released from dying cells is required for antiviral immunity in mice. Abstract »  
Peter R. Stern
28 February 2012: ec68.
Coordinating the right and left sides of the brain is mediated by the inhibition of activation in neuronal dendrites. Abstract »  
Laura M. Zahn
28 February 2012: ec69.
The comparison of two closely related parasitoid wasps reveals the genetic bases for differences in size and shape of male Nasonia wings. Abstract »  
Annalisa M. VanHook
28 February 2012: ec70.
A polyglutamine repeat–containing protein functions in developmentally programmed, nonapoptotic cell death in the nematode. Abstract »  


Editorial Guides

Wei Wong
28 February 2012: eg3.
Research reveals new mechanisms for cell migration and chemotaxis. Abstract »   Full Text »   PDF »  


Research Articles

C. Joanne Wang, Adriel Bergmann, Benjamin Lin, Kyuri Kim, and Andre Levchenko
28 February 2012: ra17.
Dictyostelium cells with increased responsiveness to chemoattractant may promote propagation of the initial signal across the cell population. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Priyanka Tibarewal, Georgios Zilidis, Laura Spinelli, Nick Schurch, Helene Maccario, Alexander Gray, Nevin M. Perera, Lindsay Davidson, Geoffrey J. Barton, and Nick R. Leslie
28 February 2012: ra18.
The lipid and protein phosphatase activities of PTEN are both required for glioma cell invasion and many of its effects on gene expression. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Stephen E. Moss
28 February 2012: pe7.
The relative concentrations of different phosphoinositide species may dictate whether actin comets or membrane ruffles are formed. Abstract »   Full Text »   PDF »  
Pablo A. Iglesias
28 February 2012: pe8.
Dictyostelium cells sense and interpret gradients by combining an incoherent feedforward loop and an amplification step. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882