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Editors' Choice

Annalisa M. VanHook
6 March 2012: ec71.
A matrix metalloprotease activates phosphoinositide 3-kinase signaling to regulate immune responses independently of its protease activity. Abstract »  
John F. Foley
6 March 2012: ec72.
Cells subjected to nonlethal mechanical stress release the cytokine interleukin-33. Abstract »  
Pamela J. Hines
6 March 2012: ec73.
New leaves emerge where they are allowed. Abstract »  
Valda Vinson
6 March 2012: ec74.
Selective effects of different ligands provide insights into the structural plasticity of receptor signaling. Abstract »  

 

Podcasts

John G. Albeck, Joan S. Brugge, and Annalisa M. VanHook
6 March 2012: pc5.
Signaling from two growth factors converges on the cell cycle inhibitor p57 to regulate proliferation and limit oncogenesis. Abstract »   Full Text »   Podcast »  

 

Research Articles

Devin T. Worster, Tobias Schmelzle, Nicole L. Solimini, Eric S. Lightcap, Bjorn Millard, Gordon B. Mills, Joan S. Brugge, and John G. Albeck
6 March 2012: ra19.
The cell cycle inhibitor p57 is induced by Akt but suppressed by ERK to control growth factor–induced proliferation and limit oncogenic behavior. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yasuo Tanaka and Zhijian J. Chen
6 March 2012: ra20.
The adaptor protein STING recruits a kinase and a transcription factor to mediate responses to cytosolic DNA. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Andrew Bowie
6 March 2012: pe9.
The adaptor STING recruits a kinase and a transcription factor to mediate the response to cytosolic DNA. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882