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Editors' Choice

Nancy R. Gough
13 March 2012: ec75.
Sphingolipids from other organellar membranes set the threshold for mitochondrial permeabilization leading to cell death. Abstract »  
Annalisa M. VanHook
13 March 2012: ec76.
Closely related hydrolases allow plants to distinguish between chemically similar compounds that elicit distinct physiological responses. Abstract »  
John F. Foley
13 March 2012: ec77.
The kinase Akt1 specifically enhances type I interferon responses by relieving the repression of interferon-stimulated genes. Abstract »  
Kristen L. Mueller
13 March 2012: ec78.
The RNA binding protein Lin28 drives fetal modes of immune cell development. Abstract »  
Peter R. Stern
13 March 2012: ec79.
A specific set of functional properties can be attributed to immature granule cells developing in the hippocampus. Abstract »  
Annalisa M. VanHook
13 March 2012: ec80.
The FERM domain protein Pez is required for Hippo signaling to restrict stem cell proliferation in the fly gut. Abstract »  


Research Articles

Ben Brankatschk, Sven P. Wichert, Shem D. Johnson, Olivier Schaad, Moritz J. Rossner, and Jean Gruenberg
13 March 2012: ra21.
The transcriptional response to EGFR activation is rapidly initiated after receptor stimulation before degradative sorting occurs. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Toren Finkel
13 March 2012: pe10.
New techniques have revealed the dynamics of posttranslational modifications triggered by redox signaling that target cysteine residues. Abstract »   Full Text »   PDF »  



13 March 2012: er2.
The authors correct a sequence range in the Materials and Methods section. Full Text »   PDF »  


Research Resources

Alex N. Nguyen Ba, Brian J. Yeh, Dewald van Dyk, Alan R. Davidson, Brenda J. Andrews, Eric L. Weiss, and Alan M. Moses
13 March 2012: rs1.
A statistical analysis method can identify short, functionally important linear motifs in disordered regions of proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882