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Editors' Choice

Nancy R. Gough
20 March 2012: ec81.
Pyruvate kinase M2 phosphorylates the transcription factor STAT3. Abstract »  
Wei Wong
20 March 2012: ec82.
The kinase Akt and the transcription factor Foxo1 may not be required for hepatic responses to insulin. Abstract »  
Nancy R. Gough
20 March 2012: ec83.
Glycyl-tRNA synthetase released from macrophages promotes tumor cell death. Abstract »  
Annalisa M. VanHook
20 March 2012: ec84.
Copper promotes MAPK signaling by enhancing MEK-mediated phosphorylation of ERK. Abstract »  
Elizabeth M. Adler
20 March 2012: ec85.
Presence of variant form of the lipid-sensing G protein–coupled receptor GPR120 with impaired function is associated with obesity. Abstract »  
Pamela J. Hines
20 March 2012: ec86.
Elucidation of the biosynthetic pathway of a new plant hormone variant that may be useful in agricultural settings is shown. Abstract »  
Valda K. Vinson
20 March 2012: ec87.
Whereas one fusion protein complex can fuse a vesicle with a bilayer, three are needed for efficient content release. Abstract »  
Stella M. Hurtley
20 March 2012: ec88.
Tracking of individual synaptic vesicles reveals that kiss-and-run fusion is concentrated near the center of the synapse. Abstract »  
Sacha N. Vignieri
20 March 2012: ec89.
In laboratory experiments, male fruit flies respond to lack of sex by increasing alcohol consumption. Abstract »  
Pamela J. Hines
20 March 2012: ec90.
A mutation known to cause cataracts also disables a specialized mechanosensory receptor in mice and humans. Abstract »  


Research Articles

Eugene Varfolomeev, Tatiana Goncharov, Heather Maecker, Kerry Zobel, László G. Kömüves, Kurt Deshayes, and Domagoj Vucic
20 March 2012: ra22.
Signaling downstream of tumor necrosis factor family receptors hinges on the presence or absence of c-IAP proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Wook Kim, Qizong Lao, Yu-Kyong Shin, Olga D. Carlson, Eun Kyung Lee, Myriam Gorospe, Rohit N. Kulkarni, and Josephine M. Egan
20 March 2012: ra23.
Activation of cannabinoid 1 receptors prevents insulin receptors from promoting β-cell survival in the pancreas. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jinghua Lu and Peter D. Sun
20 March 2012: pe11.
TLR5 exhibits a distinct ligand-binding mechanism compared with those used by other TLRs. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882