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Editors' Choice

Peter R. Stern
27 March 2012: ec91.
The infusion of a stress hormone produces fear responses to cues that were not associated with the traumatic event itself. Abstract »  
Nancy R. Gough
27 March 2012: ec92.
Chondroitin sulfate released from injured fish triggers fear responses. Abstract »  
Annalisa M. VanHook
27 March 2012: ec93.
Structural analysis reveals how cell adhesion GPCRs and PKD proteins mediate autoproteolysis of the extracellular domain. Abstract »  
Nancy R. Gough
27 March 2012: ec94.
Neurexin and CL1 interact and can mediate cellular adhesion. Abstract »  
John F. Foley
27 March 2012: ec95.
The Tec kinase Btk holds the production of reactive oxygen species by neutrophils in check. Abstract »  
Annalisa M. VanHook
27 March 2012: ec96.
Secreted peptides cooperate with auxin to drive gravitropic responses in plants. Abstract »  
Elizabeth M. Adler
27 March 2012: ec97.
Three papers explore the relationship between isocitrate dehydrogenase (IDH) mutation and glioma, with two implicating mutant IDH in aberrant methylation and the third linking (R)-2-hydroxyglutarate to degradation of hypoxia-inducible factor. Abstract »  
Stella M. Hurtley
27 March 2012: ec98.
Bexarotene counters the effects of neurodegenerative disease in mice. Abstract »  
Pamela J. Hines
27 March 2012: ec99.
A tryptophan pyramid allows a dimeric protein to perceive ultraviolet light without an additional chromophore. Abstract »  


Editorial Guides

Nancy R. Gough
27 March 2012: eg4.
This issue highlights developments in the regulation and physiological importance of the signaling network associated with the kinase TOR. Abstract »   Full Text »   PDF »  



David J. Glass and Annalisa M. VanHook
27 March 2012: pc6.
Regulated protein synthesis and degradation mediate skeletal muscle homeostasis. Abstract »   Full Text »   Podcast »  


Research Articles

Suchithra Menon, Jessica L. Yecies, Hui H. Zhang, Jessica J. Howell, Justin Nicholatos, Eylul Harputlugil, Roderick T. Bronson, David J. Kwiatkowski, and Brendan D. Manning
27 March 2012: ra24.
Aberrant activation of the mammalian target of rapamycin complex 1 disrupts tissue homeostasis, leading to carcinogenesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Piero Dalle Pezze, Annika G. Sonntag, Antje Thien, Mirja T. Prentzell, Markus Gödel, Sven Fischer, Elke Neumann-Haefelin, Tobias B. Huber, Ralf Baumeister, Daryl P. Shanley, and Kathrin Thedieck
27 March 2012: ra25.
Modeling and testing network structures reveal a distinct mechanism of mTORC2 activation by insulin. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Diane C. Fingar and Ken Inoki
27 March 2012: pe12.
Combining classic biochemical approaches with dynamic mathematical modeling elucidates a new model for insulin-mediated activation of mTORC2. Abstract »   Full Text »   PDF »  
Brian M. Wiczer and George Thomas
27 March 2012: pe13.
Activation of PLD1 by amino acids enables mTORC1 to respond to nutrient abundance. Abstract »   Full Text »   PDF »  


Research Resources

Noah Dephoure and Steven P. Gygi
27 March 2012: rs2.
A dual-labeling strategy enables high-throughput analysis of multiple samples by mass spectrometry. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882